Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3255900..3256531 Replicon chromosome
Accession NZ_CP041130
Organism Serratia marcescens strain WVU-007

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag FG172_RS15860 Protein ID WP_033640020.1
Coordinates 3255900..3256298 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag FG172_RS15865 Protein ID WP_041035628.1
Coordinates 3256298..3256531 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T127691 WP_033640020.1 NZ_CP041130:c3256298-3255900 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T127691 NZ_CP041130:c3256298-3255900 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGCCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCAGCATCGCACTAC
GGCAACATCCGCGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGCCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT127691 WP_041035628.1 NZ_CP041130:c3256531-3256298 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT127691 NZ_CP041130:c3256531-3256298 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGATAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References