Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1233658..1234424 Replicon chromosome
Accession NZ_CP041130
Organism Serratia marcescens strain WVU-007

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag FG172_RS05935 Protein ID WP_141958300.1
Coordinates 1234056..1234424 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FG172_RS05930 Protein ID WP_141958298.1
Coordinates 1233658..1233996 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG172_RS05905 1229007..1229483 + 477 WP_141958291.1 hypothetical protein -
FG172_RS05910 1230014..1231174 + 1161 WP_141958293.1 putative lipopolysaccharide heptosyltransferase III -
FG172_RS05915 1231227..1232471 + 1245 WP_141958294.1 O-antigen ligase family protein -
FG172_RS05920 1232666..1233124 + 459 WP_141958296.1 antirestriction protein -
FG172_RS05925 1233150..1233629 + 480 WP_141960602.1 DNA repair protein RadC -
FG172_RS05930 1233658..1233996 + 339 WP_141958298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FG172_RS05935 1234056..1234424 + 369 WP_141958300.1 TA system toxin CbtA family protein Toxin
FG172_RS05940 1234421..1234750 + 330 WP_141958302.1 hypothetical protein -
FG172_RS25635 1234849..1235022 + 174 WP_159317730.1 hypothetical protein -
FG172_RS05945 1235334..1235660 + 327 WP_048322373.1 gamma-glutamylcyclotransferase -
FG172_RS25640 1235769..1235912 + 144 WP_016928795.1 hypothetical protein -
FG172_RS05950 1236038..1237579 + 1542 WP_141958304.1 glycosyltransferase family 39 protein -
FG172_RS05955 1237655..1238413 - 759 WP_087763339.1 serine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(9-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13326.30 Da        Isoelectric Point: 8.5167

>T127682 WP_141958300.1 NZ_CP041130:1234056-1234424 [Serratia marcescens]
MRTVPASPTQAAQPCPSPITVWQSLLTYLLTQHYGLTLNDTAFSDDAVIQAHLDDGISLADALNAMVEKFDLVRIDRRGF
SGLAQSPLVTAIDILRARRACGLMTRAGYREVTRTIQGGKRP

Download         Length: 369 bp

>T127682 NZ_CP041130:1234056-1234424 [Serratia marcescens]
ATGCGAACAGTACCCGCGTCACCCACACAGGCGGCTCAGCCTTGCCCATCTCCCATAACTGTCTGGCAATCCTTGCTCAC
CTACCTGCTGACGCAGCACTACGGCCTGACGCTCAACGACACCGCATTCAGCGACGATGCCGTGATACAGGCACACCTCG
ATGACGGTATCTCCCTCGCGGATGCGCTGAATGCCATGGTGGAAAAGTTTGATCTGGTGCGTATTGACCGCCGGGGCTTC
AGCGGTCTGGCGCAATCGCCCCTCGTGACTGCCATTGACATCTTGCGCGCCCGCAGGGCCTGCGGCCTGATGACGCGAGC
CGGTTACCGGGAGGTCACACGAACGATTCAGGGAGGCAAACGCCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12684.34 Da        Isoelectric Point: 6.6336

>AT127682 WP_141958298.1 NZ_CP041130:1233658-1233996 [Serratia marcescens]
MTSTKNVPSWGLKRNVTPQFGARLVQEGERLHFLADRADISGIFSDAQRYDLEKAFPQFINHLELMLLSGELNPRHQHCV
TLYSHGLTCEADSLGSYGYVYLSIYPTPEAPR

Download         Length: 339 bp

>AT127682 NZ_CP041130:1233658-1233996 [Serratia marcescens]
ATGACATCGACCAAGAACGTTCCATCCTGGGGACTGAAACGCAACGTCACACCGCAGTTTGGCGCCCGTTTGGTACAAGA
GGGGGAACGACTGCATTTTCTGGCCGACCGTGCTGACATCAGCGGAATTTTCAGCGACGCACAGCGCTATGATTTGGAGA
AGGCTTTTCCGCAGTTCATCAACCACCTGGAATTGATGCTGCTCTCCGGTGAGCTCAATCCGCGTCATCAGCACTGTGTC
ACGCTGTATAGCCATGGCCTGACCTGCGAAGCCGACAGCTTGGGCTCATACGGCTACGTTTATCTCTCGATTTATCCGAC
ACCTGAAGCGCCCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References