Detailed information of TA system TA127673

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4394696..4395365
• Replicon: chromosome
• Accession: NZ_CP041125
• Organism: Serratia marcescens strain WVU-004

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FG169_RS21195
• Protein ID: WP_060422869.1
• Coordinates: 4394696..4395118 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: FG169_RS21200
• Protein ID: WP_019455657.1
• Coordinates: 4395099..4395365 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG169_RS21175	4390586..4391104	+	519	WP_048324740.1	flavodoxin FldB	-
FG169_RS21180	4391141..4392505	-	1365	WP_141960175.1	cell envelope integrity protein CreD	-
FG169_RS21185	4392586..4394004	-	1419	WP_141960177.1	two-component system sensor histidine kinase CreC	-
FG169_RS21190	4394001..4394696	-	696	WP_033644777.1	two-component system response regulator CreB	-
FG169_RS21195	4394696..4395118	-	423	WP_060422869.1	protein YgfX	Toxin
FG169_RS21200	4395099..4395365	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
FG169_RS21205	4395686..4396678	+	993	WP_141960178.1	tRNA-modifying protein YgfZ	-
FG169_RS21210	4396717..4397214	-	498	WP_141960180.1	DUF2165 domain-containing protein	-
FG169_RS21215	4397365..4398039	-	675	WP_038871224.1	hemolysin III family protein	-
FG169_RS21220	4398223..4398831	+	609	WP_060422860.1	HD domain-containing protein	-
FG169_RS21225	4398864..4399790	-	927	WP_141960182.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16438.50 Da
• Isoelectric Point: 10.8114

>T127673 WP_060422869.1 NZ_CP041125:c4395118-4394696 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T127673 NZ_CP041125:c4395118-4394696 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTGGGCCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAAAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGTTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGTGAGGAGGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT127673 WP_019455657.1 NZ_CP041125:c4395365-4395099 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT127673 NZ_CP041125:c4395365-4395099 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04