Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3221796..3222427 Replicon chromosome
Accession NZ_CP041125
Organism Serratia marcescens strain WVU-004

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag FG169_RS15635 Protein ID WP_033640020.1
Coordinates 3221796..3222194 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag FG169_RS15640 Protein ID WP_041035628.1
Coordinates 3222194..3222427 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG169_RS15610 3217370..3217741 + 372 WP_033647787.1 type II toxin-antitoxin system RelE/ParE family toxin -
FG169_RS15615 3217738..3218040 + 303 WP_038876832.1 DNA-binding transcriptional regulator -
FG169_RS15620 3218043..3218447 - 405 WP_141959524.1 flagellar protein FlhE -
FG169_RS15625 3218447..3220525 - 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
FG169_RS15630 3220518..3221669 - 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
FG169_RS15635 3221796..3222194 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
FG169_RS15640 3222194..3222427 - 234 WP_041035628.1 antitoxin Antitoxin
FG169_RS15645 3222553..3223197 - 645 WP_004934858.1 protein phosphatase CheZ -
FG169_RS15650 3223208..3223597 - 390 WP_060420785.1 chemotaxis response regulator CheY -
FG169_RS15655 3223700..3224749 - 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
FG169_RS15660 3224749..3225621 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
FG169_RS15665 3225659..3227275 - 1617 WP_047730456.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T127668 WP_033640020.1 NZ_CP041125:c3222194-3221796 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T127668 NZ_CP041125:c3222194-3221796 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGCCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCAGCATCGCACTAC
GGCAACATCCGCGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGCCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT127668 WP_041035628.1 NZ_CP041125:c3222427-3222194 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT127668 NZ_CP041125:c3222427-3222194 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGATAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References