Detailed information of TA system TA127656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 55106..55641
• Replicon: chromosome
• Accession: NZ_CP041125
• Organism: Serratia marcescens strain WVU-004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: FG169_RS00245
• Protein ID: WP_033636570.1
• Coordinates: 55366..55641 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FG169_RS00240
• Protein ID: WP_141957622.1
• Coordinates: 55106..55366 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG169_RS00220	50426..51076	+	651	WP_141957616.1	DcrB-related protein	-
FG169_RS00225	51117..51722	+	606	WP_038875954.1	glutathione S-transferase	-
FG169_RS00230	51791..53185	+	1395	WP_141957618.1	L-seryl-tRNA(Sec) selenium transferase	-
FG169_RS00235	53182..55023	+	1842	WP_141957620.1	selenocysteine-specific translation elongation factor	-
FG169_RS00240	55106..55366	+	261	WP_141957622.1	ribbon-helix-helix domain-containing protein	Antitoxin
FG169_RS00245	55366..55641	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FG169_RS00250	55653..56564	-	912	WP_141957624.1	LysR family transcriptional regulator	-
FG169_RS00255	56686..57312	+	627	WP_047729542.1	LysE family translocator	-
FG169_RS00260	57366..58613	-	1248	WP_141957626.1	MFS transporter	-
FG169_RS00265	58831..59823	+	993	WP_060441242.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T127656 WP_033636570.1 NZ_CP041125:55366-55641 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T127656 NZ_CP041125:55366-55641 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGCTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9680.04 Da
• Isoelectric Point: 4.5084

>AT127656 WP_141957622.1 NZ_CP041125:55106-55366 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHELVEAWAASLDSDD
PLPVPR

Nucleotide

• Length: 261 bp

>AT127656 NZ_CP041125:55106-55366 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTTGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D971