Detailed information of TA system TA127648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3974578..3975234
• Replicon: chromosome
• Accession: NZ_CP041123
• Organism: Serratia marcescens strain WVU-002

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: FBF86_RS19175
• Protein ID: WP_047730091.1
• Coordinates: 3974578..3974967 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: FBF86_RS19180
• Protein ID: WP_004941563.1
• Coordinates: 3974971..3975234 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBF86_RS19160	3971048..3972478	+	1431	WP_185741746.1	MFS transporter	-
FBF86_RS19165	3972475..3973857	+	1383	WP_141959918.1	two-component system sensor histidine kinase BaeS	-
FBF86_RS19170	3973857..3974573	+	717	WP_060441150.1	two-component system response regulator BaeR	-
FBF86_RS19175	3974578..3974967	-	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
FBF86_RS19180	3974971..3975234	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FBF86_RS19185	3975573..3975911	+	339	WP_038873760.1	YegP family protein	-
FBF86_RS19190	3976213..3977565	+	1353	WP_060424878.1	tRNA 5-hydroxyuridine modification protein YegQ	-
FBF86_RS19195	3978032..3978937	+	906	WP_060424880.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T127648 WP_047730091.1 NZ_CP041123:c3974967-3974578 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T127648 NZ_CP041123:c3974967-3974578 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACCTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAGAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTTGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT127648 WP_004941563.1 NZ_CP041123:c3975234-3974971 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT127648 NZ_CP041123:c3975234-3974971 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCTCCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A5C7DE55