Detailed information of TA system TA127636

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 1233982..1234748
• Replicon: chromosome
• Accession: NZ_CP041123
• Organism: Serratia marcescens strain WVU-002

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: FBF86_RS05950
• Protein ID: WP_141958300.1
• Coordinates: 1234380..1234748 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FBF86_RS05945
• Protein ID: WP_141958298.1
• Coordinates: 1233982..1234320 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBF86_RS05920	1229331..1229807	+	477	WP_141958291.1	hypothetical protein	-
FBF86_RS05925	1230338..1231498	+	1161	WP_141958293.1	putative lipopolysaccharide heptosyltransferase III	-
FBF86_RS05930	1231551..1232795	+	1245	WP_141958294.1	O-antigen ligase family protein	-
FBF86_RS05935	1232990..1233448	+	459	WP_141958296.1	antirestriction protein	-
FBF86_RS05940	1233474..1233953	+	480	WP_141960602.1	DNA repair protein RadC	-
FBF86_RS05945	1233982..1234320	+	339	WP_141958298.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FBF86_RS05950	1234380..1234748	+	369	WP_141958300.1	TA system toxin CbtA family protein	Toxin
FBF86_RS05955	1234745..1235074	+	330	WP_141958302.1	hypothetical protein	-
FBF86_RS25505	1235173..1235346	+	174	WP_159317730.1	hypothetical protein	-
FBF86_RS05960	1235657..1235983	+	327	WP_048322373.1	gamma-glutamylcyclotransferase	-
FBF86_RS25510	1236092..1236235	+	144	WP_016928795.1	hypothetical protein	-
FBF86_RS05965	1236361..1237902	+	1542	WP_141958304.1	glycosyltransferase family 39 protein	-
FBF86_RS05970	1237978..1238736	-	759	WP_087763339.1	serine O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1187573..1260725	73152

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (9-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13326.30 Da
• Isoelectric Point: 8.5167

>T127636 WP_141958300.1 NZ_CP041123:1234380-1234748 [Serratia marcescens]
MRTVPASPTQAAQPCPSPITVWQSLLTYLLTQHYGLTLNDTAFSDDAVIQAHLDDGISLADALNAMVEKFDLVRIDRRGF
SGLAQSPLVTAIDILRARRACGLMTRAGYREVTRTIQGGKRP

Nucleotide

• Length: 369 bp

>T127636 NZ_CP041123:1234380-1234748 [Serratia marcescens]
ATGCGAACAGTACCCGCGTCACCCACACAGGCGGCTCAGCCTTGCCCATCTCCCATAACTGTCTGGCAATCCTTGCTCAC
CTACCTGCTGACGCAGCACTACGGCCTGACGCTCAACGACACCGCATTCAGCGACGATGCCGTGATACAGGCACACCTCG
ATGACGGTATCTCCCTCGCGGATGCGCTGAATGCCATGGTGGAAAAGTTTGATCTGGTGCGTATTGACCGCCGGGGCTTC
AGCGGTCTGGCGCAATCGCCCCTCGTGACTGCCATTGACATCTTGCGCGCCCGCAGGGCCTGCGGCCTGATGACGCGAGC
CGGTTACCGGGAGGTCACACGAACGATTCAGGGAGGCAAACGCCCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12684.34 Da
• Isoelectric Point: 6.6336

>AT127636 WP_141958298.1 NZ_CP041123:1233982-1234320 [Serratia marcescens]
MTSTKNVPSWGLKRNVTPQFGARLVQEGERLHFLADRADISGIFSDAQRYDLEKAFPQFINHLELMLLSGELNPRHQHCV
TLYSHGLTCEADSLGSYGYVYLSIYPTPEAPR

Nucleotide

• Length: 339 bp

>AT127636 NZ_CP041123:1233982-1234320 [Serratia marcescens]
ATGACATCGACCAAGAACGTTCCATCCTGGGGACTGAAACGCAACGTCACACCGCAGTTTGGCGCCCGTTTGGTACAAGA
GGGGGAACGACTGCATTTTCTGGCCGACCGTGCTGACATCAGCGGAATTTTCAGCGACGCACAGCGCTATGATTTGGAGA
AGGCTTTTCCGCAGTTCATCAACCACCTGGAATTGATGCTGCTCTCCGGTGAGCTCAATCCGCGTCATCAGCACTGTGTC
ACGCTGTATAGCCATGGCCTGACCTGCGAAGCCGACAGCTTGGGCTCATACGGCTACGTTTATCTCTCGATTTATCCGAC
ACCTGAAGCGCCCAGGTAA