Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1796380..1797211 Replicon chromosome
Accession NZ_CP041110
Organism Escherichia coli strain ECCTRSRTH03

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag CI675_RS08530 Protein ID WP_000854818.1
Coordinates 1796380..1796754 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag CI675_RS08535 Protein ID WP_001313071.1
Coordinates 1796843..1797211 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI675_RS08495 1792376..1792705 + 330 WP_000450409.1 DUF496 family protein -
CI675_RS08500 1792806..1792988 - 183 WP_001016348.1 hypothetical protein -
CI675_RS08505 1793042..1793188 + 147 Protein_1660 transposase domain-containing protein -
CI675_RS08510 1793552..1794298 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
CI675_RS08515 1794313..1795854 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
CI675_RS08520 1796063..1796176 - 114 WP_001161660.1 DUF957 domain-containing protein -
CI675_RS08525 1796189..1796383 - 195 WP_000988600.1 hypothetical protein -
CI675_RS08530 1796380..1796754 - 375 WP_000854818.1 type IV toxin-antitoxin system toxin CbtA Toxin
CI675_RS08535 1796843..1797211 - 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CI675_RS08540 1797291..1797512 - 222 WP_000692301.1 DUF987 domain-containing protein -
CI675_RS08545 1797575..1798051 - 477 WP_001186726.1 RadC family protein -
CI675_RS08550 1798067..1798546 - 480 WP_000860076.1 antirestriction protein -
CI675_RS08555 1798628..1799449 - 822 WP_001234530.1 DUF945 domain-containing protein -
CI675_RS08565 1799670..1800080 - 411 WP_000846713.1 hypothetical protein -
CI675_RS08570 1800096..1800779 - 684 WP_042004735.1 hypothetical protein -
CI675_RS08575 1800915..1801985 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T127605 WP_000854818.1 NZ_CP041110:c1796754-1796380 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T127605 NZ_CP041110:c1796754-1796380 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT127605 WP_001313071.1 NZ_CP041110:c1797211-1796843 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT127605 NZ_CP041110:c1797211-1796843 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References