127597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 17840..18305 Replicon plasmid unnamed6
Accession NZ_CP041105
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH07

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag CI661_RS29205 Protein ID WP_001230707.1
Coordinates 18054..18305 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag CI661_RS29200 Protein ID WP_000801440.1
Coordinates 17840..18067 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI661_RS29150 13070..13285 - 216 WP_000760375.1 EexN family lipoprotein -
CI661_RS29155 13282..13575 - 294 WP_094327203.1 LuxR family transcriptional regulator -
CI661_RS29160 13652..14881 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
CI661_RS29165 14885..15388 - 504 WP_000781813.1 hypothetical protein -
CI661_RS29175 15749..16096 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
CI661_RS29180 16093..16341 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
CI661_RS29185 16646..16996 - 351 WP_000854259.1 hypothetical protein -
CI661_RS29190 17087..17386 - 300 WP_000650309.1 hypothetical protein -
CI661_RS29200 17840..18067 - 228 WP_000801440.1 hypothetical protein Antitoxin
CI661_RS29205 18054..18305 - 252 WP_001230707.1 hypothetical protein Toxin
CI661_RS29210 18302..18844 - 543 WP_001083906.1 hypothetical protein -
CI661_RS29215 18949..19464 - 516 WP_001025395.1 J domain-containing protein -
CI661_RS29225 20857..21723 + 867 WP_001353743.1 replication initiation protein -
CI661_RS29230 21736..22140 + 405 WP_012421203.1 hypothetical protein -
CI661_RS29235 22275..22802 + 528 WP_094327205.1 DUF2726 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..31229 31229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>T127597 WP_001230707.1 NZ_CP041105:c18305-18054 [Klebsiella pneumoniae subsp. pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>T127597 NZ_CP041105:c18305-18054 [Klebsiella pneumoniae subsp. pneumoniae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 11203.44 Da        Isoelectric Point: 5.5500

>AT127597 WP_000801440.1 NZ_CP041105:c18067-17840 [Klebsiella pneumoniae subsp. pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 228 bp

>AT127597 NZ_CP041105:c18067-17840 [Klebsiella pneumoniae subsp. pneumoniae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References