Detailed information of TA system TA127596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 15749..16341
• Replicon: plasmid unnamed6
• Accession: NZ_CP041105
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH07

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: V0AGQ2
• Locus tag: CI661_RS29180
• Protein ID: WP_000520549.1
• Coordinates: 16093..16341 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: V0AWG0
• Locus tag: CI661_RS29175
• Protein ID: WP_000681613.1
• Coordinates: 15749..16096 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CI661_RS29140	11754..12026	-	273	WP_001328551.1	TrbC/VirB2 family protein	-
CI661_RS29145	12094..12714	-	621	WP_000157549.1	lytic transglycosylase domain-containing protein	-
CI661_RS29150	13070..13285	-	216	WP_000760375.1	EexN family lipoprotein	-
CI661_RS29155	13282..13575	-	294	WP_094327203.1	LuxR family transcriptional regulator	-
CI661_RS29160	13652..14881	-	1230	WP_001329504.1	relaxase/mobilization nuclease domain-containing protein	-
CI661_RS29165	14885..15388	-	504	WP_000781813.1	hypothetical protein	-
CI661_RS29175	15749..16096	-	348	WP_000681613.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CI661_RS29180	16093..16341	-	249	WP_000520549.1	type II toxin-antitoxin system HicA family toxin	Toxin
CI661_RS29185	16646..16996	-	351	WP_000854259.1	hypothetical protein	-
CI661_RS29190	17087..17386	-	300	WP_000650309.1	hypothetical protein	-
CI661_RS29200	17840..18067	-	228	WP_000801440.1	hypothetical protein	-
CI661_RS29205	18054..18305	-	252	WP_001230707.1	hypothetical protein	-
CI661_RS29210	18302..18844	-	543	WP_001083906.1	hypothetical protein	-
CI661_RS29215	18949..19464	-	516	WP_001025395.1	J domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..31229	31229

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 12233.67 Da
• Isoelectric Point: 5.5500

>T127596 WP_000520549.1 NZ_CP041105:c16341-16093 [Klebsiella pneumoniae subsp. pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Nucleotide

• Length: 249 bp

>T127596 NZ_CP041105:c16341-16093 [Klebsiella pneumoniae subsp. pneumoniae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTT

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 17090.50 Da
• Isoelectric Point: 5.5500

>AT127596 WP_000681613.1 NZ_CP041105:c16096-15749 [Klebsiella pneumoniae subsp. pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 348 bp

>AT127596 NZ_CP041105:c16096-15749 [Klebsiella pneumoniae subsp. pneumoniae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A829CIX3

Antitoxin

• AlphaFold DB: A0A829CLC1