Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 54884..55620 Replicon plasmid unnamed1
Accession NZ_CP041100
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH07

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag CI661_RS26200 Protein ID WP_003026803.1
Coordinates 55138..55620 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag CI661_RS26195 Protein ID WP_003026799.1
Coordinates 54884..55150 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI661_RS26150 50946..51308 - 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -
CI661_RS26155 51358..51708 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
CI661_RS26160 52066..52335 + 270 WP_004152102.1 hypothetical protein -
CI661_RS26165 52323..52898 + 576 WP_004152103.1 hypothetical protein -
CI661_RS26170 52929..53423 + 495 WP_004152104.1 DNA-binding protein -
CI661_RS26175 53467..53835 + 369 WP_004152105.1 hypothetical protein -
CI661_RS26180 53869..54072 + 204 WP_004152106.1 hemolysin expression modulator Hha -
CI661_RS26185 54121..54378 + 258 WP_004152107.1 hypothetical protein -
CI661_RS26190 54454..54708 + 255 WP_004152108.1 hypothetical protein -
CI661_RS26195 54884..55150 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
CI661_RS26200 55138..55620 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
CI661_RS26205 55832..57178 + 1347 WP_020314316.1 ISNCY family transposase -
CI661_RS26210 57679..58933 - 1255 Protein_59 IS3 family transposase -
CI661_RS26215 59021..59983 - 963 WP_004152113.1 M48 family metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..194739 194739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 20654.05 Da        Isoelectric Point: 13.0041

>T127593 WP_003026803.1 NZ_CP041100:55138-55620 [Klebsiella pneumoniae subsp. pneumoniae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Download         Length: 483 bp

>T127593 NZ_CP041100:55138-55620 [Klebsiella pneumoniae subsp. pneumoniae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 11425.51 Da        Isoelectric Point: 12.7445

>AT127593 WP_003026799.1 NZ_CP041100:54884-55150 [Klebsiella pneumoniae subsp. pneumoniae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKK

Download         Length: 267 bp

>AT127593 NZ_CP041100:54884-55150 [Klebsiella pneumoniae subsp. pneumoniae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References