Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4656694..4657210 Replicon chromosome
Accession NZ_CP041092
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH01

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CI667_RS22600 Protein ID WP_002886902.1
Coordinates 4656694..4656978 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CI667_RS22605 Protein ID WP_002886901.1
Coordinates 4656968..4657210 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI667_RS22580 4652090..4652398 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CI667_RS28770 4652483..4652656 + 174 WP_040248667.1 hypothetical protein -
CI667_RS22585 4652659..4653402 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CI667_RS22590 4653759..4655897 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CI667_RS22595 4656226..4656690 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CI667_RS22600 4656694..4656978 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CI667_RS22605 4656968..4657210 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CI667_RS22610 4657288..4659198 - 1911 WP_064278334.1 BglG family transcription antiterminator -
CI667_RS22615 4659221..4660375 - 1155 WP_094487804.1 lactonase family protein -
CI667_RS22620 4660442..4661182 - 741 WP_094487803.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T127586 WP_002886902.1 NZ_CP041092:c4656978-4656694 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T127586 NZ_CP041092:c4656978-4656694 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCAGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT127586 WP_002886901.1 NZ_CP041092:c4657210-4656968 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT127586 NZ_CP041092:c4657210-4656968 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References