Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4352744..4353381 Replicon chromosome
Accession NZ_CP041091
Organism Nocardioides sambongensis strain KUDC 5002

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FIV43_RS20340 Protein ID WP_181407811.1
Coordinates 4352744..4353130 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FIV43_RS20345 Protein ID WP_141015584.1
Coordinates 4353130..4353381 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV43_RS20315 4347942..4349288 + 1347 WP_181407617.1 MFS transporter -
FIV43_RS20320 4349364..4350008 + 645 WP_196780912.1 TetR/AcrR family transcriptional regulator -
FIV43_RS20325 4350030..4351100 - 1071 WP_141015580.1 phosphotransferase family protein -
FIV43_RS20330 4351097..4352248 - 1152 WP_141015581.1 acyl-CoA dehydrogenase family protein -
FIV43_RS20335 4352380..4352721 + 342 WP_141015582.1 DUF2200 domain-containing protein -
FIV43_RS20340 4352744..4353130 - 387 WP_181407811.1 type II toxin-antitoxin system VapC family toxin Toxin
FIV43_RS20345 4353130..4353381 - 252 WP_141015584.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FIV43_RS20350 4353463..4355037 - 1575 WP_141015585.1 AMP-binding protein -
FIV43_RS20355 4355027..4355569 - 543 WP_141015586.1 2,4'-dihydroxyacetophenone dioxygenase family protein -
FIV43_RS20360 4355566..4356627 - 1062 WP_181407618.1 iron-containing alcohol dehydrogenase -
FIV43_RS20365 4356714..4357703 - 990 WP_141015588.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13535.32 Da        Isoelectric Point: 4.8782

>T127570 WP_181407811.1 NZ_CP041091:c4353130-4352744 [Nocardioides sambongensis]
IVADTSPLVAIVLGESDAERHLTELVRERCLISAASVVEATIVVEARQGPDATRDLEHLIGSVADRIVPVDADHAAVAVG
AWRRFGKGRHPAGLNYGDCFSYATARIAGLPLLFKGDDFGQTDIASAL

Download         Length: 387 bp

>T127570 NZ_CP041091:c4353130-4352744 [Nocardioides sambongensis]
ATCGTCGCGGACACCTCACCCCTGGTGGCCATCGTCCTCGGCGAGAGCGACGCGGAGCGCCATCTCACCGAGCTGGTCCG
GGAACGGTGCCTGATCTCGGCGGCTTCGGTGGTCGAGGCGACGATCGTCGTCGAAGCACGACAGGGACCTGACGCCACGC
GGGATCTCGAACATCTCATTGGCTCGGTGGCCGATCGCATCGTGCCGGTCGATGCCGACCACGCAGCGGTCGCGGTCGGC
GCATGGCGCCGCTTCGGCAAGGGACGTCACCCCGCAGGGCTGAACTATGGCGATTGCTTCTCCTACGCCACCGCCCGAAT
CGCCGGGCTCCCGCTGCTGTTCAAGGGAGACGACTTCGGCCAGACCGATATCGCGAGCGCGCTATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9112.25 Da        Isoelectric Point: 4.8362

>AT127570 WP_141015584.1 NZ_CP041091:c4353381-4353130 [Nocardioides sambongensis]
MALNIKDAETDRLARELAELTGQSITVALREALQDKLAVARARRAVAGTDDLQAIIDRGRARRILDDRTSEDIVGYDEHG
LPA

Download         Length: 252 bp

>AT127570 NZ_CP041091:c4353381-4353130 [Nocardioides sambongensis]
ATGGCGCTCAACATCAAGGACGCGGAGACCGACCGCCTGGCACGCGAGCTCGCCGAGCTGACCGGGCAGTCGATCACCGT
CGCACTGCGCGAAGCACTGCAGGACAAGCTCGCAGTTGCGCGAGCCCGGCGCGCAGTCGCCGGGACCGACGACTTGCAGG
CCATCATCGACCGCGGGCGTGCGCGACGCATCCTCGACGACCGCACGAGCGAGGACATCGTCGGGTACGACGAGCACGGC
CTGCCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References