Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3812526..3813213 Replicon chromosome
Accession NZ_CP041091
Organism Nocardioides sambongensis strain KUDC 5002

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FIV43_RS17735 Protein ID WP_181407572.1
Coordinates 3812782..3813213 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FIV43_RS17730 Protein ID WP_141015198.1
Coordinates 3812526..3812795 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV43_RS17710 3808266..3808802 - 537 WP_196781122.1 TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator -
FIV43_RS17715 3809010..3810554 + 1545 WP_141015195.1 fatty acid desaturase -
FIV43_RS17720 3810638..3811138 + 501 Protein_3557 TetR family transcriptional regulator -
FIV43_RS17725 3811233..3812468 + 1236 WP_141015197.1 M15 family metallopeptidase -
FIV43_RS17730 3812526..3812795 + 270 WP_141015198.1 ribbon-helix-helix protein, CopG family Antitoxin
FIV43_RS17735 3812782..3813213 + 432 WP_181407572.1 PIN domain-containing protein Toxin
FIV43_RS17740 3813276..3814436 + 1161 WP_141016045.1 CoA transferase -
FIV43_RS17745 3814443..3815801 - 1359 WP_141015200.1 signal peptidase I -
FIV43_RS21200 3815822..3817039 - 1218 WP_181407573.1 Ig-like domain repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-135)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15634.91 Da        Isoelectric Point: 5.1976

>T127569 WP_181407572.1 NZ_CP041091:3812782-3813213 [Nocardioides sambongensis]
VLFCDVNVLVHALRPEQSAEAERVRDWLESTIVSGMPIGVAELVLSAVARLTTSQRLFSPATTPAEFVEFSETLLAAPTV
DVVRPGPRHWAIFTGLLTDHRLRGNDVPDAYLASIALERGATLVTRDRGFGRFAELRVLDPIG

Download         Length: 432 bp

>T127569 NZ_CP041091:3812782-3813213 [Nocardioides sambongensis]
GTGCTGTTCTGTGACGTCAACGTGCTGGTGCACGCGCTGCGTCCGGAACAGAGCGCCGAAGCCGAGCGGGTCCGTGACTG
GCTGGAGTCGACGATCGTCAGTGGAATGCCGATCGGTGTCGCCGAGCTGGTGCTGTCGGCCGTCGCGCGGCTGACAACCA
GTCAACGGCTGTTCTCGCCCGCCACCACGCCTGCCGAGTTCGTCGAGTTCTCCGAGACCCTCCTCGCCGCGCCCACCGTC
GATGTCGTGCGTCCCGGGCCGCGACACTGGGCGATCTTCACGGGCCTGCTGACCGATCACAGGCTCCGCGGAAACGACGT
GCCCGATGCCTACCTCGCCTCGATCGCGCTGGAGCGTGGCGCGACCCTGGTGACGCGCGACCGGGGCTTCGGCCGGTTCG
CGGAGTTGCGCGTGCTCGACCCCATCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9580.78 Da        Isoelectric Point: 4.3943

>AT127569 WP_141015198.1 NZ_CP041091:3812526-3812795 [Nocardioides sambongensis]
VRTTVSIDDDLLARAKVLAAQSHRSIGSVLEEALRALLEARAAAEHPDGGAFRLPRFDYPVPAEGAAIDLYDREVVEDLL
GEGDVRAVL

Download         Length: 270 bp

>AT127569 NZ_CP041091:3812526-3812795 [Nocardioides sambongensis]
GTGCGCACGACGGTCTCGATCGACGACGACCTCCTCGCCCGGGCGAAGGTGCTCGCAGCTCAATCGCACCGCAGCATCGG
ATCGGTCCTGGAGGAGGCGCTGCGCGCGCTGCTGGAGGCTCGGGCGGCCGCGGAGCACCCAGATGGGGGCGCGTTCCGGT
TGCCGCGGTTCGACTATCCGGTGCCTGCAGAGGGTGCCGCGATCGACCTCTACGACCGAGAGGTCGTGGAGGATTTGCTC
GGCGAGGGCGACGTACGTGCTGTTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References