Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799126..799783 Replicon chromosome
Accession NZ_CP041082
Organism Klebsiella pneumoniae strain Kp202

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FJV42_RS04010 Protein ID WP_002916310.1
Coordinates 799373..799783 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FJV42_RS04005 Protein ID WP_002916312.1
Coordinates 799126..799392 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJV42_RS03980 794282..795715 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
FJV42_RS03985 795834..796562 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FJV42_RS03990 796612..796923 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FJV42_RS03995 797087..797746 + 660 WP_002916317.1 hemolysin III family protein -
FJV42_RS04000 797897..798880 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FJV42_RS04005 799126..799392 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FJV42_RS04010 799373..799783 + 411 WP_002916310.1 protein YgfX Toxin
FJV42_RS04015 799790..800311 - 522 WP_004144730.1 flavodoxin FldB -
FJV42_RS04020 800412..801308 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FJV42_RS04025 801331..802044 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FJV42_RS04030 802050..803783 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T127547 WP_002916310.1 NZ_CP041082:799373-799783 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T127547 NZ_CP041082:799373-799783 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT127547 WP_002916312.1 NZ_CP041082:799126-799392 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT127547 NZ_CP041082:799126-799392 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References