Detailed information of TA system TA127545

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2040513..2041056
• Replicon: chromosome
• Accession: NZ_CP041070
• Organism: Arcobacter anaerophilus strain DSM 24636

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AANAER_RS10150
• Protein ID: WP_129081112.1
• Coordinates: 2040513..2040812 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AANAER_RS10155
• Protein ID: WP_129081113.1
• Coordinates: 2040802..2041056 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AANAER_RS10125	2036526..2036714	-	189	WP_044418079.1	50S ribosomal protein L28	-
AANAER_RS10130	2036868..2037668	+	801	WP_129081109.1	DNA ligase	-
AANAER_RS10135	2037665..2038528	-	864	WP_044418077.1	glycosyltransferase family 4 protein	-
AANAER_RS10140	2038535..2039101	-	567	WP_129081110.1	D-sedoheptulose 7-phosphate isomerase	-
AANAER_RS10145	2039102..2040526	-	1425	WP_129081111.1	D-glycero-beta-D-manno-heptose-7-phosphate kinase	-
AANAER_RS10150	2040513..2040812	-	300	WP_129081112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AANAER_RS10155	2040802..2041056	-	255	WP_129081113.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AANAER_RS10160	2041123..2042133	-	1011	WP_129081114.1	ADP-glyceromanno-heptose 6-epimerase	-
AANAER_RS10165	2042235..2043572	-	1338	WP_129081115.1	sugar transferase	-
AANAER_RS10170	2043652..2044392	-	741	WP_129081116.1	WecB/TagA/CpsF family glycosyltransferase	-
AANAER_RS10175	2044382..2045278	-	897	WP_164969312.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-58)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11799.73 Da
• Isoelectric Point: 10.4742

>T127545 WP_129081112.1 NZ_CP041070:c2040812-2040513 [Arcobacter anaerophilus]
MTYKLKFTKESLKDWNKLDSTVKEQFKKNLKQRLENPKVPKDKLSGYENVYKIKLRSAGYRLAYEVKDKEIVILVLSVGK
RENNSIYENLKKRKENDKS

Nucleotide

• Length: 300 bp

>T127545 NZ_CP041070:c2040812-2040513 [Arcobacter anaerophilus]
ATGACTTATAAATTAAAATTTACAAAAGAGTCTTTAAAAGATTGGAATAAATTAGATTCAACAGTAAAAGAACAGTTTAA
AAAAAACTTAAAGCAAAGACTTGAAAATCCAAAAGTTCCAAAAGATAAATTAAGCGGCTATGAAAATGTATATAAAATCA
AGTTACGAAGTGCAGGATATAGACTTGCTTATGAAGTAAAAGATAAAGAAATAGTTATTTTAGTATTGAGTGTAGGCAAA
AGAGAAAATAATAGTATATATGAAAATTTGAAGAAAAGAAAAGAAAATGATAAAAGTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9606.98 Da
• Isoelectric Point: 4.2457

>AT127545 WP_129081113.1 NZ_CP041070:c2041056-2040802 [Arcobacter anaerophilus]
MQAILSNYTASITELKKSPSQLLKDAGDEAVAILNHNVPSAYLVPSELYEKMMDIIDDYYLAQEVEKRLKYKKEDLIEVN
IDDL

Nucleotide

• Length: 255 bp

>AT127545 NZ_CP041070:c2041056-2040802 [Arcobacter anaerophilus]
ATGCAAGCTATTCTTTCAAACTATACAGCAAGTATAACAGAGCTTAAAAAATCACCGAGTCAACTTTTAAAAGATGCAGG
TGATGAGGCTGTAGCTATTTTAAATCATAATGTTCCAAGTGCTTATCTGGTTCCAAGTGAACTTTATGAAAAAATGATGG
ACATCATAGATGATTATTATTTAGCCCAAGAAGTTGAAAAAAGGTTAAAATATAAAAAAGAAGATTTAATTGAAGTAAAT
ATTGATGACTTATAA