Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 2212464..2212993 Replicon chromosome
Accession NZ_CP041061
Organism Micromonospora sp. HM134

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FJK98_RS09865 Protein ID WP_145918750.1
Coordinates 2212464..2212721 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FJK98_RS09870 Protein ID WP_145918751.1
Coordinates 2212718..2212993 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJK98_RS09835 2207492..2209462 - 1971 Protein_1934 DUF3416 domain-containing protein -
FJK98_RS09840 2209623..2209928 + 306 WP_145918745.1 hypothetical protein -
FJK98_RS09845 2209997..2210308 + 312 WP_145918746.1 hypothetical protein -
FJK98_RS09850 2210604..2210831 - 228 WP_145918747.1 winged helix-turn-helix domain-containing protein -
FJK98_RS33125 2211041..2211235 + 195 WP_168222409.1 hypothetical protein -
FJK98_RS09860 2211252..2212454 + 1203 WP_168222410.1 helix-turn-helix domain-containing protein -
FJK98_RS09865 2212464..2212721 - 258 WP_145918750.1 Txe/YoeB family addiction module toxin Toxin
FJK98_RS09870 2212718..2212993 - 276 WP_145918751.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FJK98_RS09875 2213038..2214222 - 1185 WP_194821660.1 glycogen synthase -
FJK98_RS09880 2214336..2215568 + 1233 WP_145918753.1 glucose-1-phosphate adenylyltransferase -
FJK98_RS09885 2215639..2217276 + 1638 WP_145918754.1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10178.59 Da        Isoelectric Point: 9.4580

>T127531 WP_145918750.1 NZ_CP041061:c2212721-2212464 [Micromonospora sp. HM134]
VRLVFTATAWNQYLSHTDRKLVKRINDLIADVMRNEYEGIGKPEPLRGELSGFWSRRIDREHRLVYRVTKDDVEIIACRY
HYGDR

Download         Length: 258 bp

>T127531 NZ_CP041061:c2212721-2212464 [Micromonospora sp. HM134]
GTGAGGCTGGTCTTCACCGCGACGGCGTGGAACCAGTACCTCAGCCACACGGATCGCAAGCTGGTCAAACGCATCAACGA
TCTCATCGCGGACGTCATGCGCAACGAGTACGAGGGCATCGGCAAGCCGGAGCCCCTCCGGGGTGAGCTCTCCGGCTTCT
GGTCCCGCCGGATCGATCGCGAACACCGGCTGGTGTACCGGGTCACCAAGGACGACGTCGAGATCATTGCCTGCCGATAC
CACTACGGCGACAGGTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10097.27 Da        Isoelectric Point: 4.1634

>AT127531 WP_145918751.1 NZ_CP041061:c2212993-2212718 [Micromonospora sp. HM134]
MRTVNFTQLRQNLAAELDSVINDAEEVVVTRSGHEPVVIVPLAEYESMKETEYLLRSPGNAAALRRSIAELEEGDATERE
LVDPTTVRDVA

Download         Length: 276 bp

>AT127531 NZ_CP041061:c2212993-2212718 [Micromonospora sp. HM134]
ATGCGGACCGTCAACTTCACCCAGCTACGGCAGAACCTGGCCGCCGAACTCGACAGCGTCATCAACGACGCGGAGGAAGT
GGTCGTGACCCGGTCGGGTCACGAGCCGGTGGTCATCGTGCCGCTGGCGGAGTACGAGTCGATGAAGGAGACCGAGTACC
TGCTGCGCAGTCCGGGCAACGCCGCAGCCCTGCGCAGATCGATCGCGGAGCTCGAAGAGGGTGACGCCACCGAGCGGGAA
CTGGTTGACCCGACGACCGTACGGGACGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References