Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4636710..4637341 Replicon chromosome
Accession NZ_CP041051
Organism Citrobacter sp. CF971

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag E6P06_RS26025 Protein ID WP_003837806.1
Coordinates 4637066..4637341 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag E6P06_RS26020 Protein ID WP_003837808.1
Coordinates 4636710..4637069 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6P06_RS25990 4631806..4632471 + 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
E6P06_RS25995 4632544..4633101 + 558 WP_003837816.1 DcrB family lipoprotein -
E6P06_RS26000 4633105..4634322 - 1218 WP_016151126.1 MFS transporter -
E6P06_RS26005 4634456..4635505 + 1050 WP_003023393.1 AI-2E family transporter -
E6P06_RS26010 4635568..4636146 + 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
E6P06_RS26015 4636196..4636597 + 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
E6P06_RS26020 4636710..4637069 - 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E6P06_RS26025 4637066..4637341 - 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
E6P06_RS26030 4637419..4638543 - 1125 WP_003837801.1 ABC transporter permease -
E6P06_RS26035 4638543..4641290 - 2748 WP_049025788.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T127529 WP_003837806.1 NZ_CP041051:c4637341-4637066 [Citrobacter sp. CF971]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T127529 NZ_CP041051:c4637341-4637066 [Citrobacter sp. CF971]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT127529 WP_003837808.1 NZ_CP041051:c4637069-4636710 [Citrobacter sp. CF971]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT127529 NZ_CP041051:c4637069-4636710 [Citrobacter sp. CF971]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References