Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4066330..4066984 Replicon chromosome
Accession NZ_CP041051
Organism Citrobacter sp. CF971

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag E6P06_RS23165 Protein ID WP_003026936.1
Coordinates 4066330..4066737 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag E6P06_RS23170 Protein ID WP_003026938.1
Coordinates 4066718..4066984 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6P06_RS23145 4062273..4064006 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
E6P06_RS23150 4064012..4064725 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E6P06_RS23155 4064754..4065650 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
E6P06_RS23160 4065764..4066285 + 522 WP_003026933.1 flavodoxin FldB -
E6P06_RS23165 4066330..4066737 - 408 WP_003026936.1 protein YgfX Toxin
E6P06_RS23170 4066718..4066984 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
E6P06_RS23175 4067241..4068221 + 981 WP_139935772.1 tRNA-modifying protein YgfZ -
E6P06_RS23180 4068315..4068974 - 660 WP_096878467.1 hemolysin III family protein -
E6P06_RS23185 4069137..4069448 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
E6P06_RS23190 4069501..4070229 + 729 WP_003026952.1 MurR/RpiR family transcriptional regulator -
E6P06_RS23195 4070350..4071783 + 1434 WP_139935773.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T127527 WP_003026936.1 NZ_CP041051:c4066737-4066330 [Citrobacter sp. CF971]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T127527 NZ_CP041051:c4066737-4066330 [Citrobacter sp. CF971]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT127527 WP_003026938.1 NZ_CP041051:c4066984-4066718 [Citrobacter sp. CF971]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT127527 NZ_CP041051:c4066984-4066718 [Citrobacter sp. CF971]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References