127516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 722435..723111 Replicon chromosome
Accession NZ_CP041051
Organism Citrobacter sp. CF971

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag E6P06_RS06965 Protein ID WP_110249215.1
Coordinates 722773..723111 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag E6P06_RS06960 Protein ID WP_126957115.1
Coordinates 722435..722737 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6P06_RS06925 717460..717666 - 207 WP_047359073.1 AlpA family transcriptional regulator -
E6P06_RS06930 717769..718356 - 588 WP_047359072.1 inovirus-type Gp2 protein -
E6P06_RS06935 718952..720139 + 1188 WP_110249205.1 hypothetical protein -
E6P06_RS06940 720243..721106 + 864 WP_110249206.1 GTPase family protein -
E6P06_RS06945 721198..721680 + 483 WP_139935062.1 antirestriction protein -
E6P06_RS06950 721696..722172 + 477 WP_126957113.1 RadC family protein -
E6P06_RS06955 722181..722402 + 222 WP_110249213.1 DUF987 domain-containing protein -
E6P06_RS06960 722435..722737 + 303 WP_126957115.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E6P06_RS06965 722773..723111 + 339 WP_110249215.1 TA system toxin CbtA family protein Toxin
E6P06_RS06970 723226..724059 + 834 WP_110249234.1 DUF4942 domain-containing protein -
E6P06_RS06975 724292..725089 + 798 WP_110249216.1 helix-turn-helix transcriptional regulator -
E6P06_RS06985 725249..726121 - 873 WP_139935063.1 HNH endonuclease -
E6P06_RS06990 726262..726897 + 636 WP_139935064.1 HNH endonuclease -
E6P06_RS06995 726950..727312 - 363 WP_139935065.1 endoribonuclease SymE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(2-99)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12794.80 Da        Isoelectric Point: 10.1435

>T127516 WP_110249215.1 NZ_CP041051:722773-723111 [Citrobacter sp. CF971]
MKSLPANQRVAKPCPPPVLVWQTLLTRLLKQHYGLALNDTPFSDENVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQKQSPYLRAVDILRARQATGLLRQSYHPSTR

Download         Length: 339 bp

>T127516 NZ_CP041051:722773-723111 [Citrobacter sp. CF971]
ATGAAATCTCTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCAGTACTTGTCTGGCAAACGCTACTTACACG
CCTGCTGAAGCAACACTACGGCTTGGCACTGAACGATACACCATTCAGTGATGAGAACGTTATTCAGGAGCATATCAACG
CCGGTATTACGCTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGTTTTAAC
TGTCAGAAGCAATCACCTTATCTTCGGGCAGTAGATATTTTACGGGCAAGGCAAGCAACCGGCCTTTTGCGGCAAAGCTA
TCATCCTTCGACACGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11497.99 Da        Isoelectric Point: 5.5420

>AT127516 WP_126957115.1 NZ_CP041051:722435-722737 [Citrobacter sp. CF971]
MGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTDELNPRHAHCITLYQDELTC
EADTLGSYGYVYIVIYPTQR

Download         Length: 303 bp

>AT127516 NZ_CP041051:722435-722737 [Citrobacter sp. CF971]
ATGGGGCTGCAGCGGGATATCACACCGCGCCTGGGGGCCCGTCTGGTACAGGAAGGAAACCGGCTGCACTATCTGGCTGA
CCGGGCCAGCATCACTGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGCACTTTATCAGCCAGA
TGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGTCATGCGCACTGCATCACTCTGTACCAGGACGAACTCACGTGT
GAAGCAGATACTCTGGGTTCCTATGGCTATGTCTATATAGTCATCTATCCCACTCAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References