Detailed information of TA system TA127501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1997689..1998218
• Replicon: chromosome
• Accession: NZ_CP041037
• Organism: Staphylococcus aureus strain NP66

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: FIV54_RS10255
• Protein ID: WP_001103939.1
• Coordinates: 1997689..1998006 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: FIV54_RS10260
• Protein ID: WP_145326170.1
• Coordinates: 1998057..1998218 (-)
• Length: 54 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV54_RS10230	1993695..1994336	-	642	WP_001019807.1	hypothetical protein	-
FIV54_RS10235	1994333..1994617	-	285	WP_000998185.1	hypothetical protein	-
FIV54_RS10240	1994619..1994981	-	363	WP_001039170.1	hypothetical protein	-
FIV54_RS10245	1995282..1996739	-	1458	WP_000390453.1	virulence-associated E family protein	-
FIV54_RS10250	1996756..1997625	-	870	WP_145326168.1	primase alpha helix C-terminal domain-containing protein	-
FIV54_RS10255	1997689..1998006	-	318	WP_001103939.1	DUF1474 family protein	Toxin
FIV54_RS10260	1998057..1998218	-	162	WP_145326170.1	pathogenicity island protein	Antitoxin
FIV54_RS10265	1998211..1998357	-	147	WP_000784885.1	hypothetical protein	-
FIV54_RS10270	1998369..1998587	-	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
FIV54_RS10275	1998623..1998826	-	204	WP_001045296.1	transcriptional regulator	-
FIV54_RS10280	1998962..1999765	+	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
FIV54_RS10285	1999755..2000861	+	1107	WP_000149511.1	site-specific integrase	-
FIV54_RS10295	2001424..2001888	-	465	WP_001085185.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sell / sec	1986322..2004282	17960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T127501 WP_001103939.1 NZ_CP041037:c1998006-1997689 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T127501 NZ_CP041037:c1998006-1997689 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 54 a.a.
• Molecular weight: 6319.14 Da
• Isoelectric Point: 4.3644

>AT127501 WP_145326170.1 NZ_CP041037:c1998218-1998057 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMK

Nucleotide

• Length: 162 bp

>AT127501 NZ_CP041037:c1998218-1998057 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
AG

Structures

Toxin

• AlphaFold DB: K7ZRX6