Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1971669..1972146 Replicon chromosome
Accession NZ_CP041037
Organism Staphylococcus aureus strain NP66

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FIV54_RS10110 Protein ID WP_000052076.1
Coordinates 1971958..1972146 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FIV54_RS10105 Protein ID WP_001059690.1
Coordinates 1971669..1971929 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV54_RS10070 1967062..1967778 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
FIV54_RS10075 1967926..1968348 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
FIV54_RS10080 1968747..1969241 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
FIV54_RS10085 1969396..1970013 + 618 WP_000255547.1 LysE/ArgO family amino acid transporter -
FIV54_RS10090 1970086..1970667 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
FIV54_RS10095 1970892..1971128 + 237 WP_000368687.1 hypothetical protein -
FIV54_RS10100 1971125..1971328 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FIV54_RS10105 1971669..1971929 + 261 WP_001059690.1 hypothetical protein Antitoxin
FIV54_RS10110 1971958..1972146 + 189 WP_000052076.1 hypothetical protein Toxin
FIV54_RS10115 1972334..1972903 + 570 WP_001106651.1 hypothetical protein -
FIV54_RS10120 1972991..1973275 + 285 WP_001004401.1 hypothetical protein -
FIV54_RS10125 1973337..1973555 + 219 WP_000005886.1 hypothetical protein -
FIV54_RS10130 1974051..1974251 - 201 WP_001059082.1 cold-shock protein -
FIV54_RS10135 1974608..1975294 - 687 WP_001806958.1 thermonuclease family protein -
FIV54_RS10140 1975635..1976117 - 483 WP_000824468.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)

Antitoxin

Toxin YoeB

(7-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T127500 WP_000052076.1 NZ_CP041037:1971958-1972146 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T127500 NZ_CP041037:1971958-1972146 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT127500 WP_001059690.1 NZ_CP041037:1971669-1971929 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT127500 NZ_CP041037:1971669-1971929 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References