Detailed information of TA system TA127482

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 490578..491219
• Replicon: chromosome
• Accession: NZ_CP041035
• Organism: Acinetobacter baumannii strain 11W359501

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: B0V6V2
• Locus tag: FIM01_RS02380
• Protein ID: WP_000931890.1
• Coordinates: 490830..491219 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: FIM01_RS02375
• Protein ID: WP_011860336.1
• Coordinates: 490578..490823 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIM01_RS02355	486082..487089	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
FIM01_RS02360	487108..487485	+	378	WP_001216380.1	50S ribosomal protein L17	-
FIM01_RS02365	487666..489156	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
FIM01_RS02370	489206..490378	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
FIM01_RS02375	490578..490823	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
FIM01_RS02380	490830..491219	+	390	WP_000931890.1	membrane protein	Toxin
FIM01_RS02385	491989..493074	+	1086	WP_000049106.1	hypothetical protein	-
FIM01_RS02390	493152..493718	+	567	WP_000651536.1	rhombosortase	-
FIM01_RS02395	493906..496101	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15649.98 Da
• Isoelectric Point: 10.4623

>T127482 WP_000931890.1 NZ_CP041035:490830-491219 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T127482 NZ_CP041035:490830-491219 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT127482 WP_011860336.1 NZ_CP041035:490578-490823 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT127482 NZ_CP041035:490578-490823 [Acinetobacter baumannii]
ATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTTTGACCCTTATGT
GAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAGATCCTGATTTAC
TCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAACACTATGTTCAT
GGTTAA

Structures

Toxin

• AlphaFold DB: A0A0J1A4U0