Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 101867..102450 Replicon chromosome
Accession NZ_CP041030
Organism Francisella sp. LA112445 strain LA11-2445

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FIP56_RS00500 Protein ID WP_192577054.1
Coordinates 101867..102121 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FIP56_RS00505 Protein ID WP_192577055.1
Coordinates 102118..102450 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIP56_RS00475 97320..97763 - 444 WP_192577049.1 6,7-dimethyl-8-ribityllumazine synthase -
FIP56_RS00480 97773..98984 - 1212 WP_192577050.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
FIP56_RS00485 98977..99582 - 606 WP_192577051.1 riboflavin synthase -
FIP56_RS00490 99575..100645 - 1071 WP_192577052.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
FIP56_RS00495 101111..101668 - 558 WP_192577053.1 recombinase family protein -
FIP56_RS00500 101867..102121 + 255 WP_192577054.1 type II toxin-antitoxin system HicA family toxin Toxin
FIP56_RS00505 102118..102450 + 333 WP_192577055.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FIP56_RS00510 102453..104057 + 1605 WP_192577056.1 DDE-type integrase/transposase/recombinase -
FIP56_RS00515 104057..105028 + 972 WP_192577057.1 AAA family ATPase -
FIP56_RS00520 105352..106605 + 1254 WP_192577058.1 sodium:proton antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 99575..121102 21527
- flank IS/Tn - - 101111..101668 557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9795.62 Da        Isoelectric Point: 10.5226

>T127456 WP_192577054.1 NZ_CP041030:101867-102121 [Francisella sp. LA112445]
MSKIEKLITRFLSEPKDFEWTELKKLLISLGYEEFNSGKTSGSRVKFISKKHADISLHKPHPTPILKKYQIKQIKELLKK
EGLV

Download         Length: 255 bp

>T127456 NZ_CP041030:101867-102121 [Francisella sp. LA112445]
ATGAGTAAAATAGAAAAGCTTATAACAAGATTTCTATCAGAGCCAAAGGATTTTGAATGGACTGAGTTAAAAAAGTTATT
GATCAGTTTAGGGTATGAAGAATTTAACTCAGGTAAAACAAGCGGTTCAAGAGTGAAGTTTATATCTAAAAAGCATGCTG
ATATAAGTTTACATAAACCTCATCCAACACCGATACTTAAAAAATATCAAATAAAGCAAATTAAAGAACTTCTAAAAAAG
GAGGGACTAGTATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12555.03 Da        Isoelectric Point: 4.6026

>AT127456 WP_192577055.1 NZ_CP041030:102118-102450 [Francisella sp. LA112445]
MNNLIKYKGYYGSVEFDEESMVFYGQVQFIRSLISYEAENAKELIDSFHSSIEEYLEDCRERGVEPEKAFRGSLNVRLGT
DLHEKVAIAASNMGTSINDFIKQTLNKNTA

Download         Length: 333 bp

>AT127456 NZ_CP041030:102118-102450 [Francisella sp. LA112445]
ATGAATAATTTAATTAAATATAAAGGATATTATGGCTCAGTTGAGTTTGATGAAGAAAGCATGGTTTTTTATGGTCAAGT
TCAATTCATTAGAAGTCTTATATCTTATGAGGCTGAAAATGCTAAAGAGTTAATTGATAGCTTTCATAGTTCTATAGAGG
AATATCTAGAAGATTGTAGAGAAAGAGGTGTTGAACCTGAGAAAGCATTTAGAGGTTCACTAAATGTTAGACTAGGCACA
GATCTACATGAAAAAGTAGCTATCGCAGCTAGTAATATGGGCACTAGTATTAATGACTTTATAAAACAAACCCTTAATAA
AAACACTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References