Detailed information of TA system TA127452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3103971..3105099
• Replicon: chromosome
• Accession: NZ_CP041025
• Organism: Paremcibacter congregatus strain ZYLT

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV45_RS13735
• Protein ID: WP_165777111.1
• Coordinates: 3104314..3105099 (+)
• Length: 262 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV45_RS13730
• Protein ID: WP_099475172.1
• Coordinates: 3103971..3104327 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV45_RS13710	3099326..3101323	-	1998	WP_181040080.1	BCCT family transporter	-
FIV45_RS13715	3101574..3102053	+	480	WP_099475175.1	MarR family transcriptional regulator	-
FIV45_RS13720	3102180..3102833	+	654	WP_099475174.1	2OG-Fe(II) oxygenase	-
FIV45_RS13725	3103193..3103774	+	582	WP_099475173.1	discoidin domain-containing protein	-
FIV45_RS13730	3103971..3104327	+	357	WP_099475172.1	DUF2384 domain-containing protein	Antitoxin
FIV45_RS13735	3104314..3105099	+	786	WP_165777111.1	RES family NAD+ phosphorylase	Toxin
FIV45_RS18490	3105148..3105501	+	354	WP_165777110.1	hypothetical protein	-
FIV45_RS18625	3107217..3107420	+	204	WP_204602407.1	SEC-C domain-containing protein	-
FIV45_RS13750	3107584..3107829	-	246	WP_204602380.1	helix-turn-helix domain-containing protein	-
FIV45_RS13755	3108169..3108900	+	732	WP_099475167.1	hypothetical protein	-
FIV45_RS13760	3108998..3109612	+	615	WP_099475166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (66-214)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (12-59)

Sequences

Toxin

Protein

• Length: 262 a.a.
• Molecular weight: 28660.76 Da
• Isoelectric Point: 5.7195

>T127452 WP_165777111.1 NZ_CP041025:3104314-3105099 [Paremcibacter congregatus]
VEKYSLPAPDRIKAAITPDIHGLVWRVVESQEQVATLDLVETLEEQALLEKLLEESKPPLPDGCAGLDYLLATPFRYPPL
KWGSRFGSPYEPSLFYGAAQIPTALAETAYYRVLFWTGMATPPPSGALKTQHTVFSVPYRCAAGLSLNAAPFEECQDLLR
HPTDYGATQYLGARLRALGVDGFTFVSARCPDRGLNIALFTPTALAAKRPREKQTWLCETSARHVMFSGPERGQGQGQLL
KFDGEDFRIAAEAVPPALPPQ

Nucleotide

• Length: 786 bp

>T127452 NZ_CP041025:3104314-3105099 [Paremcibacter congregatus]
GTGGAAAAATATAGCCTTCCCGCACCAGACCGGATCAAAGCCGCGATCACCCCGGACATCCACGGCCTCGTCTGGCGGGT
GGTGGAAAGCCAGGAACAGGTCGCCACGCTGGATCTGGTCGAGACACTGGAAGAACAGGCCCTGCTGGAAAAACTGCTGG
AGGAGTCCAAACCGCCGCTGCCCGACGGCTGCGCAGGTCTGGATTATCTGCTGGCCACGCCGTTTCGCTACCCGCCGCTA
AAATGGGGTTCGCGCTTTGGCAGCCCGTATGAGCCCAGTCTTTTTTATGGCGCGGCGCAGATCCCGACGGCGCTGGCGGA
AACCGCTTACTATCGGGTTTTATTCTGGACCGGCATGGCGACGCCGCCGCCGTCCGGCGCGCTCAAGACACAGCATACGG
TCTTCTCGGTCCCCTACCGATGCGCCGCCGGCCTGTCGTTAAACGCCGCCCCGTTTGAGGAGTGTCAGGACCTGCTGCGC
CATCCGACAGACTATGGCGCGACGCAATATCTCGGCGCGCGCTTAAGAGCGCTCGGCGTTGATGGCTTTACCTTCGTCTC
CGCCCGCTGCCCGGACAGGGGGCTCAATATCGCGCTTTTCACCCCGACGGCGCTGGCCGCGAAACGGCCCCGGGAAAAAC
AGACCTGGCTCTGTGAAACCTCGGCCCGGCATGTTATGTTCAGCGGCCCGGAACGGGGACAAGGACAGGGCCAATTGCTG
AAATTTGACGGTGAAGATTTCCGGATCGCCGCCGAAGCCGTCCCCCCGGCCCTCCCGCCGCAATGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12774.92 Da
• Isoelectric Point: 9.9804

>AT127452 WP_099475172.1 NZ_CP041025:3103971-3104327 [Paremcibacter congregatus]
MTALALKETTDDVVLAKAVLKTAKALGLTQEELGQILGRDRTSIARGLNPSSKAGELALCLIRCYRALFVVVGGEAGAIK
HWFSTQNHHTRGVPKEQAKTIQGLVHILEYLDAIRGKI

Nucleotide

• Length: 357 bp

>AT127452 NZ_CP041025:3103971-3104327 [Paremcibacter congregatus]
ATGACCGCCCTCGCGCTGAAAGAAACCACCGATGACGTTGTTCTGGCAAAGGCCGTGTTGAAAACAGCCAAGGCGCTGGG
CCTGACACAGGAAGAGCTCGGTCAGATCCTCGGCCGCGACCGCACCTCCATTGCCCGCGGGCTCAACCCGTCCAGCAAGG
CGGGGGAACTCGCGCTGTGTCTGATCCGCTGTTACCGGGCGCTGTTTGTCGTCGTCGGCGGCGAGGCCGGGGCGATCAAA
CACTGGTTCTCCACCCAGAACCACCATACCCGGGGCGTGCCCAAGGAACAGGCCAAGACCATTCAGGGGCTTGTCCATAT
TCTTGAATATCTGGACGCCATTCGTGGAAAAATATAG