Detailed information of TA system TA127450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2179284..2180385
• Replicon: chromosome
• Accession: NZ_CP041025
• Organism: Paremcibacter congregatus strain ZYLT

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV45_RS09880
• Protein ID: WP_204602361.1
• Coordinates: 2179627..2180385 (+)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV45_RS09875
• Protein ID: WP_204602359.1
• Coordinates: 2179284..2179640 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV45_RS09860	2175542..2176141	-	600	WP_099474955.1	hypothetical protein	-
FIV45_RS18600	2176815..2177483	-	669	WP_204602370.1	recombinase zinc beta ribbon domain-containing protein	-
FIV45_RS18605	2177901..2178404	-	504	Protein_1961	recombinase family protein	-
FIV45_RS09875	2179284..2179640	+	357	WP_204602359.1	DUF2384 domain-containing protein	Antitoxin
FIV45_RS09880	2179627..2180385	+	759	WP_204602361.1	RES domain-containing protein	Toxin
FIV45_RS09885	2180412..2180651	-	240	WP_099474959.1	hypothetical protein	-
FIV45_RS09890	2180704..2180895	-	192	WP_099474960.1	hypothetical protein	-
FIV45_RS09895	2181259..2181867	-	609	WP_099474961.1	zeta toxin family protein	-
FIV45_RS09900	2181876..2182214	-	339	WP_099475022.1	ParD-like family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2176812..2285379	108567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (65-215)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (14-63)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28438.49 Da
• Isoelectric Point: 5.4052

>T127450 WP_204602361.1 NZ_CP041025:2179627-2180385 [Paremcibacter congregatus]
VEKFNLPSIDLIKTAIVSKIRGIAWRVVESQEEIATLELVDTLEEQAILEGLLEKSKPPLPENCRDLDYLLATPFRYPPL
KWGSRFGRKHEPSLFYGSENIPTALAETAYYRVLFWTGMAEPPPSGTLKTQHTIYSTKYDCSAGLYLNKPPFEEYQDLLQ
HPQDYSGSQKLGTIMRELGVDGFQFISARCPNKGLNIALFTPYALAAKRPDEKQNWICETSEQHIMFSGQGVLFKFNVEG
FQIDGKAPLPAS

Nucleotide

• Length: 759 bp

>T127450 NZ_CP041025:2179627-2180385 [Paremcibacter congregatus]
GTGGAAAAATTTAATCTTCCCTCAATAGACCTGATTAAAACGGCAATTGTTTCCAAAATTAGGGGTATCGCTTGGCGTGT
TGTGGAAAGTCAGGAAGAAATTGCCACACTGGAACTTGTTGATACGCTGGAAGAACAAGCAATTTTAGAAGGGCTTCTTG
AGAAATCCAAGCCTCCTCTCCCTGAGAACTGTCGTGATCTGGACTATTTATTAGCAACCCCCTTTCGTTATCCCCCCTTA
AAATGGGGTTCCCGATTTGGGCGCAAACATGAGCCTAGTCTTTTTTATGGCTCAGAAAATATTCCAACGGCCCTCGCAGA
AACAGCCTATTACCGGGTTTTATTCTGGACAGGGATGGCGGAACCTCCCCCGTCTGGCACACTTAAAACACAACATACGA
TTTATTCTACAAAATATGACTGTTCGGCTGGATTATATTTAAACAAGCCTCCTTTTGAAGAATATCAGGACTTGCTCCAG
CATCCTCAGGATTATAGTGGATCACAGAAACTTGGCACGATCATGAGAGAATTGGGTGTAGACGGCTTTCAATTCATCTC
CGCACGCTGCCCTAACAAGGGTTTGAATATTGCACTTTTTACCCCTTATGCACTCGCCGCAAAACGACCAGATGAAAAGC
AGAACTGGATATGTGAAACTTCTGAACAGCATATTATGTTTAGCGGACAAGGGGTTTTATTTAAATTTAACGTCGAAGGT
TTCCAAATTGACGGGAAAGCCCCCCTACCCGCCAGCTAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13054.13 Da
• Isoelectric Point: 8.0738

>AT127450 WP_204602359.1 NZ_CP041025:2179284-2179640 [Paremcibacter congregatus]
MTALTIEETNDELVLAKAVLKTAKALGLTQEELGQILGRDRTSIARGLNPSSKAGELALYLIRCYRSLFVVVGGEAENIK
HWFTTMNHHTNGVPKEQVKNIQGLVHILEYLDAIRGKI

Nucleotide

• Length: 357 bp

>AT127450 NZ_CP041025:2179284-2179640 [Paremcibacter congregatus]
TTGACGGCTCTAACTATTGAAGAAACCAACGATGAACTTGTTCTGGCAAAGGCTGTTTTAAAAACAGCCAAAGCATTGGG
TTTAACGCAGGAAGAACTCGGTCAAATATTAGGTCGGGACCGTACGTCTATTGCACGCGGTCTAAACCCTTCCAGTAAGG
CGGGAGAACTGGCCCTCTATCTTATTCGCTGTTACCGCTCTTTATTTGTTGTCGTCGGCGGAGAAGCGGAGAATATCAAA
CATTGGTTTACCACCATGAACCACCATACAAATGGTGTCCCCAAAGAACAGGTGAAGAATATTCAAGGTCTTGTCCATAT
TCTTGAATATCTGGATGCCATTCGTGGAAAAATTTAA