Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1023194..1023768 | Replicon | chromosome |
| Accession | NZ_CP041017 | ||
| Organism | Sphingobium fuliginis ATCC 27551 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | FIL70_RS22970 | Protein ID | WP_140043417.1 |
| Coordinates | 1023194..1023526 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | FIL70_RS22975 | Protein ID | WP_140043418.1 |
| Coordinates | 1023526..1023768 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FIL70_RS26155 | 1018490..1018951 | - | 462 | WP_208759639.1 | hypothetical protein | - |
| FIL70_RS26160 | 1018958..1019224 | - | 267 | WP_208759640.1 | zeta toxin family protein | - |
| FIL70_RS22940 | 1019221..1019541 | - | 321 | WP_037481402.1 | hypothetical protein | - |
| FIL70_RS22945 | 1019857..1020956 | - | 1100 | Protein_860 | TonB-dependent receptor | - |
| FIL70_RS22950 | 1020947..1021099 | - | 153 | Protein_861 | DUF736 domain-containing protein | - |
| FIL70_RS22955 | 1021466..1021981 | + | 516 | WP_103001489.1 | hypothetical protein | - |
| FIL70_RS25895 | 1022098..1022235 | - | 138 | WP_158230081.1 | hypothetical protein | - |
| FIL70_RS22960 | 1022204..1022650 | - | 447 | WP_082166019.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FIL70_RS22965 | 1022650..1022919 | - | 270 | WP_044660855.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FIL70_RS22970 | 1023194..1023526 | - | 333 | WP_140043417.1 | endoribonuclease MazF | Toxin |
| FIL70_RS22975 | 1023526..1023768 | - | 243 | WP_140043418.1 | PbsX family transcriptional regulator | Antitoxin |
| FIL70_RS22985 | 1024470..1024727 | + | 258 | WP_048575602.1 | addiction module antitoxin | - |
| FIL70_RS22990 | 1024733..1025046 | + | 314 | Protein_869 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FIL70_RS22995 | 1025135..1025398 | - | 264 | Protein_870 | transposase | - |
| FIL70_RS23000 | 1025515..1025727 | + | 213 | WP_099186724.1 | hypothetical protein | - |
| FIL70_RS23005 | 1025974..1026348 | - | 375 | WP_044660862.1 | hypothetical protein | - |
| FIL70_RS23010 | 1026422..1027342 | - | 921 | WP_065846328.1 | LysR family transcriptional regulator | - |
| FIL70_RS23015 | 1027483..1027812 | + | 330 | WP_140043419.1 | nuclear transport factor 2 family protein | - |
| FIL70_RS23020 | 1027874..1028652 | + | 779 | Protein_875 | SDR family oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1025096..1025410 | 314 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12084.25 Da Isoelectric Point: 9.9037
>T127432 WP_140043417.1 NZ_CP041017:c1023526-1023194 [Sphingobium fuliginis ATCC 27551]
MAKYVPDMGDIVWLNFDPQAGHEQAGHRPALVLSPAAYNRVRGMMICCPMTSKIKGYPFEVLTSQNLPSAVLADQLKSVD
WMTRKATKKGTVSQAALLEIQAKIRALLAI
MAKYVPDMGDIVWLNFDPQAGHEQAGHRPALVLSPAAYNRVRGMMICCPMTSKIKGYPFEVLTSQNLPSAVLADQLKSVD
WMTRKATKKGTVSQAALLEIQAKIRALLAI
Download Length: 333 bp
>T127432 NZ_CP041017:c1023526-1023194 [Sphingobium fuliginis ATCC 27551]
ATGGCCAAATATGTCCCCGACATGGGCGATATCGTCTGGCTAAACTTTGATCCCCAGGCTGGACATGAACAGGCTGGTCA
TCGACCTGCCCTTGTCCTGTCACCGGCAGCCTATAATCGCGTGCGCGGGATGATGATTTGTTGTCCTATGACAAGCAAAA
TCAAAGGCTATCCCTTTGAGGTGTTAACCAGCCAGAACCTGCCAAGTGCTGTATTGGCAGATCAGCTCAAAAGTGTTGAC
TGGATGACACGGAAGGCGACCAAAAAAGGAACAGTATCGCAAGCGGCGCTGCTGGAAATTCAGGCAAAAATCCGTGCTCT
GTTGGCGATTTAA
ATGGCCAAATATGTCCCCGACATGGGCGATATCGTCTGGCTAAACTTTGATCCCCAGGCTGGACATGAACAGGCTGGTCA
TCGACCTGCCCTTGTCCTGTCACCGGCAGCCTATAATCGCGTGCGCGGGATGATGATTTGTTGTCCTATGACAAGCAAAA
TCAAAGGCTATCCCTTTGAGGTGTTAACCAGCCAGAACCTGCCAAGTGCTGTATTGGCAGATCAGCTCAAAAGTGTTGAC
TGGATGACACGGAAGGCGACCAAAAAAGGAACAGTATCGCAAGCGGCGCTGCTGGAAATTCAGGCAAAAATCCGTGCTCT
GTTGGCGATTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8813.12 Da Isoelectric Point: 4.5489
>AT127432 WP_140043418.1 NZ_CP041017:c1023768-1023526 [Sphingobium fuliginis ATCC 27551]
MRVRVKKWGNSASVRIPSSIMAAAALHIDQEVDVREEEARVIIEPITAPAFTLEGLLAGMKPENFPENVDFGPPVGNELW
MRVRVKKWGNSASVRIPSSIMAAAALHIDQEVDVREEEARVIIEPITAPAFTLEGLLAGMKPENFPENVDFGPPVGNELW
Download Length: 243 bp
>AT127432 NZ_CP041017:c1023768-1023526 [Sphingobium fuliginis ATCC 27551]
ATGCGAGTGCGAGTGAAAAAGTGGGGTAATAGTGCTTCGGTCAGGATTCCTTCCTCGATTATGGCCGCGGCTGCGCTGCA
TATCGATCAGGAGGTGGATGTCAGGGAAGAAGAGGCCCGGGTCATCATCGAGCCGATCACCGCACCTGCCTTCACTCTTG
AGGGGTTGCTGGCGGGCATGAAACCTGAAAACTTTCCTGAAAACGTCGATTTCGGTCCGCCTGTCGGCAATGAGCTTTGG
TAA
ATGCGAGTGCGAGTGAAAAAGTGGGGTAATAGTGCTTCGGTCAGGATTCCTTCCTCGATTATGGCCGCGGCTGCGCTGCA
TATCGATCAGGAGGTGGATGTCAGGGAAGAAGAGGCCCGGGTCATCATCGAGCCGATCACCGCACCTGCCTTCACTCTTG
AGGGGTTGCTGGCGGGCATGAAACCTGAAAACTTTCCTGAAAACGTCGATTTCGGTCCGCCTGTCGGCAATGAGCTTTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|