Detailed information of TA system TA127431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2173774..2174225
• Replicon: chromosome
• Accession: NZ_CP041016
• Organism: Sphingobium fuliginis ATCC 27551

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FIL70_RS10425
• Protein ID: WP_208759524.1
• Coordinates: 2173950..2174225 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FIL70_RS10420
• Protein ID: WP_140042217.1
• Coordinates: 2173774..2173950 (+)
• Length: 59 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIL70_RS10405	2169299..2172211	+	2913	WP_140042214.1	excinuclease ABC subunit UvrA	-
FIL70_RS10410	2172213..2173208	-	996	WP_208759523.1	hypothetical protein	-
FIL70_RS10415	2173337..2173720	+	384	WP_140042216.1	hypothetical protein	-
FIL70_RS10420	2173774..2173950	+	177	WP_140042217.1	stability determinant	Antitoxin
FIL70_RS10425	2173950..2174225	+	276	WP_208759524.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FIL70_RS10430	2174309..2175316	+	1008	WP_140042219.1	hypothetical protein	-
FIL70_RS10435	2175487..2175699	+	213	WP_007684722.1	cold-shock protein	-
FIL70_RS25760	2175762..2175938	+	177	WP_165363300.1	hypothetical protein	-
FIL70_RS10440	2176067..2176285	+	219	WP_025550213.1	hypothetical protein	-
FIL70_RS10445	2176457..2176801	+	345	WP_048577913.1	glycine zipper 2TM domain-containing protein	-
FIL70_RS10450	2176859..2177791	-	933	WP_048577912.1	FAD-binding protein	-
FIL70_RS10455	2177788..2178537	-	750	WP_140042220.1	electron transfer flavoprotein subunit beta/FixA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10361.83 Da
• Isoelectric Point: 5.0484

>T127431 WP_208759524.1 NZ_CP041016:2173950-2174225 [Sphingobium fuliginis ATCC 27551]
MLSLIWHDDALDDLEGIIDFIEGHNPAAARRIGNAIRETAERLPDYPYMYRIGRVPGTREALITPNYVLVYRAGADVIEI
LAVLHTRQQYP

Nucleotide

• Length: 276 bp

>T127431 NZ_CP041016:2173950-2174225 [Sphingobium fuliginis ATCC 27551]
ATGCTCTCCCTGATCTGGCACGATGATGCCCTTGATGATCTCGAAGGCATCATCGACTTCATAGAAGGGCACAATCCCGC
CGCCGCTCGAAGGATAGGCAACGCCATCCGTGAGACGGCCGAGCGCCTGCCCGATTATCCTTACATGTACCGCATTGGCC
GAGTTCCCGGGACACGCGAAGCCCTGATTACCCCCAACTACGTCCTCGTTTACCGCGCAGGCGCAGACGTCATCGAAATC
CTGGCCGTCCTTCACACCCGCCAACAATATCCTTGA

Antitoxin

Protein

• Length: 59 a.a.
• Molecular weight: 6813.85 Da
• Isoelectric Point: 10.2709

>AT127431 WP_140042217.1 NZ_CP041016:2173774-2173950 [Sphingobium fuliginis ATCC 27551]
MTKLTPIESEFATTEEAQAYDTWFRAKVEARMTKKSRGIPHDEVMARMQKIIDRRKNA

Nucleotide

• Length: 177 bp

>AT127431 NZ_CP041016:2173774-2173950 [Sphingobium fuliginis ATCC 27551]
ATGACCAAACTCACCCCCATCGAGTCCGAGTTCGCGACGACTGAGGAAGCTCAGGCCTACGACACATGGTTCCGCGCGAA
GGTAGAGGCGAGGATGACGAAGAAATCGCGCGGCATTCCGCACGATGAGGTCATGGCCCGGATGCAGAAGATCATTGATC
GGCGCAAGAACGCCTGA