Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6695913..6696418 Replicon chromosome
Accession NZ_CP041013
Organism Pseudomonas aeruginosa strain FDAARGOS_610

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag FIU24_RS32455 Protein ID WP_003121619.1
Coordinates 6696137..6696418 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag FIU24_RS32450 Protein ID WP_003112628.1
Coordinates 6695913..6696140 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU24_RS32425 6690931..6692424 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
FIU24_RS32430 6692593..6694020 + 1428 WP_003083784.1 GABA permease -
FIU24_RS32435 6694102..6694443 - 342 WP_003101229.1 alkylphosphonate utilization protein -
FIU24_RS32440 6694516..6695016 - 501 WP_003101228.1 LEA type 2 family protein -
FIU24_RS32445 6695117..6695737 + 621 WP_003101226.1 hypothetical protein -
FIU24_RS32450 6695913..6696140 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
FIU24_RS32455 6696137..6696418 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
FIU24_RS32460 6696718..6697626 + 909 WP_003083769.1 LysR family transcriptional regulator -
FIU24_RS32465 6697658..6698044 - 387 WP_014602345.1 aegerolysin family protein -
FIU24_RS32470 6698248..6698982 - 735 WP_003117208.1 GntR family transcriptional regulator -
FIU24_RS32475 6699083..6699769 - 687 WP_004351997.1 FadR family transcriptional regulator -
FIU24_RS32480 6699818..6701167 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T127427 WP_003121619.1 NZ_CP041013:6696137-6696418 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T127427 NZ_CP041013:6696137-6696418 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT127427 WP_003112628.1 NZ_CP041013:6695913-6696140 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT127427 NZ_CP041013:6695913-6696140 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References