Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1363840..1364533 | Replicon | chromosome |
| Accession | NZ_CP041012 | ||
| Organism | Enterococcus faecalis strain FDAARGOS_611 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A2Z6BTE2 |
| Locus tag | FIU23_RS06820 | Protein ID | WP_002364356.1 |
| Coordinates | 1363840..1364184 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | FIU23_RS06825 | Protein ID | WP_002364355.1 |
| Coordinates | 1364201..1364533 (-) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FIU23_RS06785 | 1358911..1359957 | + | 1047 | WP_002356990.1 | type II secretion system F family protein | - |
| FIU23_RS06790 | 1359957..1360232 | + | 276 | WP_002356991.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| FIU23_RS06795 | 1360229..1360672 | + | 444 | WP_137007137.1 | type II secretion system GspH family protein | - |
| FIU23_RS06800 | 1360700..1361848 | - | 1149 | WP_002364359.1 | site-specific integrase | - |
| FIU23_RS06805 | 1361945..1362673 | - | 729 | WP_002364358.1 | ion transporter | - |
| FIU23_RS06815 | 1362841..1363746 | - | 906 | WP_016630909.1 | DUF4352 domain-containing protein | - |
| FIU23_RS06820 | 1363840..1364184 | - | 345 | WP_002364356.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| FIU23_RS06825 | 1364201..1364533 | - | 333 | WP_002364355.1 | helix-turn-helix domain-containing protein | Antitoxin |
| FIU23_RS06830 | 1364845..1365021 | + | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| FIU23_RS06835 | 1365032..1365330 | + | 299 | Protein_1242 | hypothetical protein | - |
| FIU23_RS06840 | 1365369..1366094 | + | 726 | WP_002364352.1 | phage regulatory protein | - |
| FIU23_RS06845 | 1366120..1366308 | - | 189 | WP_002364350.1 | YegP family protein | - |
| FIU23_RS06850 | 1366363..1366572 | + | 210 | WP_002399426.1 | hypothetical protein | - |
| FIU23_RS06855 | 1366609..1366947 | + | 339 | WP_002364347.1 | hypothetical protein | - |
| FIU23_RS06865 | 1367232..1367786 | - | 555 | WP_002357006.1 | hypothetical protein | - |
| FIU23_RS06870 | 1368006..1368323 | + | 318 | WP_002357007.1 | hypothetical protein | - |
| FIU23_RS06875 | 1368316..1369050 | + | 735 | WP_002364345.1 | ERF family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13704.62 Da Isoelectric Point: 5.8535
>T127418 WP_002364356.1 NZ_CP041012:c1364184-1363840 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T127418 NZ_CP041012:c1364184-1363840 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAATTAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAATTAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT127418 WP_002364355.1 NZ_CP041012:c1364533-1364201 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT127418 NZ_CP041012:c1364533-1364201 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|