Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1861958..1862472 Replicon chromosome
Accession NZ_CP041010
Organism Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FIU19_RS10025 Protein ID WP_000581792.1
Coordinates 1861958..1862167 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FIU19_RS10030 Protein ID WP_000138932.1
Coordinates 1862179..1862472 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU19_RS10005 1857466..1858824 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FIU19_RS10010 1858839..1859909 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FIU19_RS10015 1860227..1861429 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FIU19_RS10020 1861693..1861830 - 138 WP_000828354.1 hypothetical protein -
FIU19_RS10025 1861958..1862167 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FIU19_RS10030 1862179..1862472 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FIU19_RS10035 1862638..1864122 + 1485 WP_023487218.1 cardiolipin synthase -
FIU19_RS10040 1864150..1864797 + 648 WP_001187629.1 HD domain-containing protein -
FIU19_RS10060 1865610..1866482 - 873 WP_000725802.1 membrane protein insertase YidC -
FIU19_RS10065 1866568..1867209 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T127400 WP_000581792.1 NZ_CP041010:c1862167-1861958 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T127400 NZ_CP041010:c1862167-1861958 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT127400 WP_000138932.1 NZ_CP041010:c1862472-1862179 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT127400 NZ_CP041010:c1862472-1862179 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References