Detailed information of TA system TA127392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 752027..752818
• Replicon: chromosome
• Accession: NZ_CP041010
• Organism: Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIU19_RS04165
• Protein ID: WP_023487066.1
• Coordinates: 752027..752491 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: FIU19_RS04170
• Protein ID: WP_000333630.1
• Coordinates: 752504..752818 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU19_RS04135	747530..748669	-	1140	WP_000843611.1	nucleotidyltransferase	-
FIU19_RS04140	748796..749353	+	558	WP_000872158.1	DUF177 domain-containing protein	-
FIU19_RS04150	749433..749606	+	174	WP_000290472.1	50S ribosomal protein L32	-
FIU19_RS04155	749723..751108	-	1386	WP_023487067.1	recombinase family protein	-
FIU19_RS04160	751315..751995	-	681	WP_000392109.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FIU19_RS04165	752027..752491	-	465	WP_023487066.1	toxin-antitoxin system toxin component	Toxin
FIU19_RS04170	752504..752818	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	Antitoxin
FIU19_RS04175	752970..753206	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
FIU19_RS04180	753220..753996	+	777	WP_001148544.1	Rha family transcriptional regulator	-
FIU19_RS04185	754022..754465	+	444	WP_023487065.1	hypothetical protein	-
FIU19_RS04190	754480..754623	+	144	WP_000939498.1	hypothetical protein	-
FIU19_RS04195	754613..754822	-	210	WP_000642492.1	hypothetical protein	-
FIU19_RS04200	755262..755447	+	186	WP_000933363.1	helix-turn-helix domain-containing protein	-
FIU19_RS04205	755449..756201	+	753	WP_023487064.1	phage antirepressor KilAC domain-containing protein	-
FIU19_RS04210	756368..756598	-	231	WP_000395455.1	hypothetical protein	-
FIU19_RS15605	756648..756785	+	138	WP_000230552.1	hypothetical protein	-
FIU19_RS04215	756778..756939	+	162	WP_000066026.1	DUF1270 family protein	-
FIU19_RS04220	757033..757293	+	261	WP_000291076.1	DUF1108 family protein	-
FIU19_RS04225	757303..757524	+	222	WP_000815403.1	DUF2483 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	744561..793733	49172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18140.52 Da
• Isoelectric Point: 4.7927

>T127392 WP_023487066.1 NZ_CP041010:c752491-752027 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Nucleotide

• Length: 465 bp

>T127392 NZ_CP041010:c752491-752027 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT127392 WP_000333630.1 NZ_CP041010:c752818-752504 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT127392 NZ_CP041010:c752818-752504 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0