Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 508065..508542 Replicon chromosome
Accession NZ_CP041010
Organism Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag FIU19_RS02890 Protein ID WP_000052077.1
Coordinates 508065..508253 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FIU19_RS02895 Protein ID WP_001059690.1
Coordinates 508282..508542 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU19_RS02860 504106..504576 + 471 WP_033841859.1 hypothetical protein -
FIU19_RS02865 504917..505603 + 687 WP_001548082.1 thermonuclease family protein -
FIU19_RS02870 505960..506160 + 201 WP_001059082.1 cold-shock protein -
FIU19_RS02875 506656..506874 - 219 WP_000005886.1 hypothetical protein -
FIU19_RS02880 506936..507220 - 285 WP_001004395.1 hypothetical protein -
FIU19_RS02885 507308..507877 - 570 WP_001106654.1 hypothetical protein -
FIU19_RS02890 508065..508253 - 189 WP_000052077.1 hypothetical protein Toxin
FIU19_RS02895 508282..508542 - 261 WP_001059690.1 hypothetical protein Antitoxin
FIU19_RS02900 508883..509086 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FIU19_RS02905 509083..509319 - 237 WP_000368687.1 hypothetical protein -
FIU19_RS02910 509544..510125 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FIU19_RS02915 510198..510815 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FIU19_RS02920 510970..511464 - 495 WP_000569886.1 GNAT family N-acetyltransferase -
FIU19_RS02925 511585..512757 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 511585..512757 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T127391 WP_000052077.1 NZ_CP041010:c508253-508065 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T127391 NZ_CP041010:c508253-508065 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT127391 WP_001059690.1 NZ_CP041010:c508542-508282 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT127391 NZ_CP041010:c508542-508282 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References