Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5579822..5580327 Replicon chromosome
Accession NZ_CP041008
Organism Pseudomonas aeruginosa strain FDAARGOS_767

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag FIU18_RS26375 Protein ID WP_003083773.1
Coordinates 5580046..5580327 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag FIU18_RS26370 Protein ID WP_003112628.1
Coordinates 5579822..5580049 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU18_RS26345 5574840..5576333 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
FIU18_RS26350 5576502..5577929 + 1428 WP_003083784.1 GABA permease -
FIU18_RS26355 5578011..5578352 - 342 WP_003101229.1 alkylphosphonate utilization protein -
FIU18_RS26360 5578425..5578925 - 501 WP_003112629.1 LEA type 2 family protein -
FIU18_RS26365 5579026..5579646 + 621 WP_003101226.1 hypothetical protein -
FIU18_RS26370 5579822..5580049 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
FIU18_RS26375 5580046..5580327 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
FIU18_RS26380 5580627..5581535 + 909 WP_003083769.1 LysR family transcriptional regulator -
FIU18_RS26385 5581567..5581953 - 387 WP_014602345.1 aegerolysin family protein -
FIU18_RS26390 5582157..5582891 - 735 WP_003115036.1 GntR family transcriptional regulator -
FIU18_RS26395 5582992..5583678 - 687 WP_003083762.1 FadR family transcriptional regulator -
FIU18_RS26400 5583727..5585076 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T127389 WP_003083773.1 NZ_CP041008:5580046-5580327 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T127389 NZ_CP041008:5580046-5580327 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT127389 WP_003112628.1 NZ_CP041008:5579822-5580049 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT127389 NZ_CP041008:5579822-5580049 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References