Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 86330..86855 Replicon plasmid unnamed1
Accession NZ_CP041006
Organism Salmonella enterica strain FDAARGOS_768

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag FIU17_RS24265 Protein ID WP_001159863.1
Coordinates 86330..86635 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag FIU17_RS24270 Protein ID WP_000813641.1
Coordinates 86637..86855 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU17_RS24225 81709..82269 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
FIU17_RS24465 82425..82712 + 288 WP_071530243.1 hypothetical protein -
FIU17_RS24230 82989..83474 - 486 WP_000905606.1 membrane protein -
FIU17_RS24235 83468..83977 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
FIU17_RS24245 83981..84694 - 714 Protein_100 EAL domain-containing protein -
FIU17_RS24250 84703..85485 - 783 WP_000082169.1 site-specific integrase -
FIU17_RS24255 85520..86041 - 522 WP_000198608.1 hypothetical protein -
FIU17_RS24260 86038..86328 - 291 WP_001266176.1 hypothetical protein -
FIU17_RS24265 86330..86635 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
FIU17_RS24270 86637..86855 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FIU17_RS24275 87531..88052 + 522 WP_010999942.1 hypothetical protein -
FIU17_RS24285 88536..88832 + 297 WP_001687482.1 hypothetical protein -
FIU17_RS24290 89326..90315 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
FIU17_RS24295 90574..91018 - 445 Protein_109 site-specific integrase -
FIU17_RS24300 91187..91568 - 382 Protein_110 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93933 93933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T127382 WP_001159863.1 NZ_CP041006:c86635-86330 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T127382 NZ_CP041006:c86635-86330 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT127382 WP_000813641.1 NZ_CP041006:c86855-86637 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT127382 NZ_CP041006:c86855-86637 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References