Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5039528..5040123 Replicon chromosome
Accession NZ_CP041002
Organism Escherichia coli strain FDAARGOS_772

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag FIU16_RS25790 Protein ID WP_000239579.1
Coordinates 5039773..5040123 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag FIU16_RS25785 Protein ID WP_001223208.1
Coordinates 5039528..5039779 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU16_RS25775 5035193..5038972 + 3780 WP_000060946.1 autotransporter assembly complex protein TamB -
FIU16_RS25780 5038975..5039316 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FIU16_RS25785 5039528..5039779 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FIU16_RS25790 5039773..5040123 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
FIU16_RS25795 5040203..5040733 - 531 WP_000055072.1 inorganic diphosphatase -
FIU16_RS25800 5041043..5041999 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FIU16_RS25805 5042309..5043811 + 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
FIU16_RS25810 5043825..5044847 + 1023 WP_001387274.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T127380 WP_000239579.1 NZ_CP041002:5039773-5040123 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T127380 NZ_CP041002:5039773-5040123 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT127380 WP_001223208.1 NZ_CP041002:5039528-5039779 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT127380 NZ_CP041002:5039528-5039779 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References