Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3570880..3571681 | Replicon | chromosome |
| Accession | NZ_CP041002 | ||
| Organism | Escherichia coli strain FDAARGOS_772 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D3GU15 |
| Locus tag | FIU16_RS18570 | Protein ID | WP_001094429.1 |
| Coordinates | 3571304..3571681 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0XUQ1 |
| Locus tag | FIU16_RS18565 | Protein ID | WP_001285616.1 |
| Coordinates | 3570880..3571257 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FIU16_RS18525 | 3567540..3567995 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| FIU16_RS18530 | 3568074..3568307 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| FIU16_RS18540 | 3568407..3569225 | + | 819 | WP_001234603.1 | DUF945 domain-containing protein | - |
| FIU16_RS18550 | 3569527..3570000 | + | 474 | WP_000855081.1 | antirestriction protein | - |
| FIU16_RS18555 | 3570016..3570492 | + | 477 | WP_001388380.1 | RadC family protein | - |
| FIU16_RS18560 | 3570579..3570800 | + | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| FIU16_RS18565 | 3570880..3571257 | + | 378 | WP_001285616.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FIU16_RS18570 | 3571304..3571681 | + | 378 | WP_001094429.1 | TA system toxin CbtA family protein | Toxin |
| FIU16_RS18575 | 3571678..3571875 | + | 198 | Protein_3456 | hypothetical protein | - |
| FIU16_RS18580 | 3571903..3572100 | + | 198 | WP_085949090.1 | DUF957 domain-containing protein | - |
| FIU16_RS18585 | 3572185..3573027 | + | 843 | WP_001280493.1 | DUF4942 domain-containing protein | - |
| FIU16_RS18590 | 3573308..3573844 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| FIU16_RS18595 | 3573846..3575024 | - | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| FIU16_RS18600 | 3575021..3575998 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| FIU16_RS18605 | 3576001..3576600 | - | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | pic / clbK / vipB/tssC / vipA/tssB / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3497492..3636501 | 139009 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13856.73 Da Isoelectric Point: 6.8601
>T127374 WP_001094429.1 NZ_CP041002:3571304-3571681 [Escherichia coli]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T127374 NZ_CP041002:3571304-3571681 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13747.65 Da Isoelectric Point: 6.6240
>AT127374 WP_001285616.1 NZ_CP041002:3570880-3571257 [Escherichia coli]
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTMTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTMTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT127374 NZ_CP041002:3570880-3571257 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCATGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCATGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVU5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XUQ1 |