Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 898872..899349 Replicon chromosome
Accession NZ_CP040998
Organism Staphylococcus aureus strain FDAARGOS_773

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FIU14_RS04550 Protein ID WP_000052078.1
Coordinates 899161..899349 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FIU14_RS04545 Protein ID WP_001059690.1
Coordinates 898872..899132 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU14_RS04510 894265..894981 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
FIU14_RS04515 895129..895551 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
FIU14_RS04520 895950..896444 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
FIU14_RS04525 896599..897216 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FIU14_RS04530 897289..897870 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
FIU14_RS04535 898095..898331 + 237 WP_000368687.1 hypothetical protein -
FIU14_RS04540 898328..898531 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FIU14_RS04545 898872..899132 + 261 WP_001059690.1 hypothetical protein Antitoxin
FIU14_RS04550 899161..899349 + 189 WP_000052078.1 hypothetical protein Toxin
FIU14_RS04555 899537..900106 + 570 WP_001106654.1 hypothetical protein -
FIU14_RS04560 900194..900478 + 285 WP_001004395.1 hypothetical protein -
FIU14_RS04565 900540..900758 + 219 WP_000005886.1 hypothetical protein -
FIU14_RS04570 901254..901454 - 201 WP_001059082.1 cold-shock protein -
FIU14_RS04575 901811..902497 - 687 WP_001548082.1 thermonuclease family protein -
FIU14_RS04580 902838..903308 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T127339 WP_000052078.1 NZ_CP040998:899161-899349 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T127339 NZ_CP040998:899161-899349 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT127339 WP_001059690.1 NZ_CP040998:898872-899132 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT127339 NZ_CP040998:898872-899132 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References