Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 826953..827565 Replicon chromosome
Accession NZ_CP040997
Organism Streptococcus pyogenes strain FDAARGOS_774

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag FIU13_RS04360 Protein ID WP_010922665.1
Coordinates 827230..827565 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag FIU13_RS04355 Protein ID WP_002988079.1
Coordinates 826953..827240 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU13_RS04325 822130..823113 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
FIU13_RS04330 823117..824046 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
FIU13_RS04335 824094..824609 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
FIU13_RS04340 824644..825072 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
FIU13_RS04345 825519..826292 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
FIU13_RS04355 826953..827240 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
FIU13_RS04360 827230..827565 + 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU13_RS10130 827717..828187 + 471 Protein_828 integrase -
FIU13_RS04370 828233..828670 + 438 WP_111713473.1 site-specific integrase -
FIU13_RS04375 828790..829182 - 393 WP_002982716.1 30S ribosomal protein S9 -
FIU13_RS04380 829203..829649 - 447 WP_002982710.1 50S ribosomal protein L13 -
FIU13_RS04385 829867..830073 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
FIU13_RS04390 830070..830576 - 507 WP_002988070.1 hypothetical protein -
FIU13_RS04395 830712..831572 - 861 WP_002982687.1 DegV family protein -
FIU13_RS04400 831669..832187 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T127337 WP_010922665.1 NZ_CP040997:827230-827565 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T127337 NZ_CP040997:827230-827565 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT127337 WP_002988079.1 NZ_CP040997:826953-827240 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT127337 NZ_CP040997:826953-827240 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References