Detailed information of TA system TA127337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 826953..827565
• Replicon: chromosome
• Accession: NZ_CP040997
• Organism: Streptococcus pyogenes strain FDAARGOS_774

Toxin (Protein)

• Gene name: parE
• Uniprot ID: J7M9F1
• Locus tag: FIU13_RS04360
• Protein ID: WP_010922665.1
• Coordinates: 827230..827565 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: FIU13_RS04355
• Protein ID: WP_002988079.1
• Coordinates: 826953..827240 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU13_RS04325	822130..823113	-	984	WP_002982755.1	tagatose-bisphosphate aldolase	-
FIU13_RS04330	823117..824046	-	930	WP_010922663.1	tagatose-6-phosphate kinase	-
FIU13_RS04335	824094..824609	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
FIU13_RS04340	824644..825072	-	429	WP_010922664.1	galactose-6-phosphate isomerase subunit LacA	-
FIU13_RS04345	825519..826292	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
FIU13_RS04355	826953..827240	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
FIU13_RS04360	827230..827565	+	336	WP_010922665.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIU13_RS10130	827717..828187	+	471	Protein_828	integrase	-
FIU13_RS04370	828233..828670	+	438	WP_111713473.1	site-specific integrase	-
FIU13_RS04375	828790..829182	-	393	WP_002982716.1	30S ribosomal protein S9	-
FIU13_RS04380	829203..829649	-	447	WP_002982710.1	50S ribosomal protein L13	-
FIU13_RS04385	829867..830073	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
FIU13_RS04390	830070..830576	-	507	WP_002988070.1	hypothetical protein	-
FIU13_RS04395	830712..831572	-	861	WP_002982687.1	DegV family protein	-
FIU13_RS04400	831669..832187	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13185.99 Da
• Isoelectric Point: 5.2144

>T127337 WP_010922665.1 NZ_CP040997:827230-827565 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T127337 NZ_CP040997:827230-827565 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT127337 WP_002988079.1 NZ_CP040997:826953-827240 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT127337 NZ_CP040997:826953-827240 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: J7M9F1

Antitoxin

• AlphaFold DB: A0A4U7GX94