Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 15453..15978 | Replicon | plasmid unnamed2 |
Accession | NZ_CP040994 | ||
Organism | Klebsiella pneumoniae strain FDAARGOS_775 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D4HQE7 |
Locus tag | FIU12_RS25955 | Protein ID | WP_013023785.1 |
Coordinates | 15453..15758 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | A0A378F352 |
Locus tag | FIU12_RS25960 | Protein ID | WP_025862266.1 |
Coordinates | 15760..15978 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FIU12_RS25925 | 12331..12708 | + | 378 | WP_162985544.1 | M15 family metallopeptidase | - |
FIU12_RS25930 | 12906..13061 | + | 156 | WP_004150747.1 | Hok/Gef family protein | - |
FIU12_RS25935 | 13185..13679 | + | 495 | Protein_12 | helix-turn-helix domain-containing protein | - |
FIU12_RS25940 | 13801..13896 | + | 96 | Protein_13 | transposase domain-containing protein | - |
FIU12_RS25945 | 14403..15197 | - | 795 | WP_025862268.1 | site-specific integrase | - |
FIU12_RS28700 | 15190..15423 | - | 234 | WP_025862267.1 | hypothetical protein | - |
FIU12_RS25955 | 15453..15758 | - | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
FIU12_RS25960 | 15760..15978 | - | 219 | WP_025862266.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
FIU12_RS25970 | 16291..16494 | + | 204 | WP_004150739.1 | hemolysin expression modulator Hha | - |
FIU12_RS25975 | 16543..16800 | + | 258 | WP_004098928.1 | hypothetical protein | - |
FIU12_RS25980 | 16859..17113 | + | 255 | WP_025862265.1 | hypothetical protein | - |
FIU12_RS25985 | 17310..17588 | + | 279 | Protein_21 | transposase | - |
FIU12_RS25990 | 18237..18797 | - | 561 | Protein_22 | porphobilinogen synthase | - |
FIU12_RS25995 | 18788..18970 | - | 183 | Protein_23 | hypothetical protein | - |
FIU12_RS26000 | 18957..19521 | - | 565 | Protein_24 | threonine--tRNA ligase | - |
FIU12_RS26010 | 19748..20692 | - | 945 | WP_004150724.1 | GTP cyclohydrolase I FolE2 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | iroB / vat | 1..96085 | 96085 | |
- | flank | IS/Tn | - | - | 13185..13697 | 512 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T127336 WP_013023785.1 NZ_CP040994:c15758-15453 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T127336 NZ_CP040994:c15758-15453 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACAGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACAGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8420.39 Da Isoelectric Point: 4.7405
>AT127336 WP_025862266.1 NZ_CP040994:c15978-15760 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISVLVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISVLVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT127336 NZ_CP040994:c15978-15760 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGTCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGTCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378F352 |