Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 754..1397 Replicon plasmid unnamed2
Accession NZ_CP040994
Organism Klebsiella pneumoniae strain FDAARGOS_775

Toxin (Protein)


Gene name vagD Uniprot ID A0A421H508
Locus tag FIU12_RS25890 Protein ID WP_001044773.1
Coordinates 981..1397 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A060VSA5
Locus tag FIU12_RS25885 Protein ID WP_001261277.1
Coordinates 754..984 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU12_RS25880 339..611 + 273 WP_044246604.1 DNA polymerase III subunit theta -
FIU12_RS25885 754..984 + 231 WP_001261277.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FIU12_RS25890 981..1397 + 417 WP_001044773.1 type II toxin-antitoxin system VapC family toxin Toxin
FIU12_RS25895 1456..1896 - 441 Protein_4 transposase family protein -
FIU12_RS27525 1884..2039 - 156 WP_164993475.1 hypothetical protein -
FIU12_RS25900 2253..2963 - 711 Protein_6 IS110 family transposase -
FIU12_RS25905 2970..3553 - 584 Protein_7 transposase zinc-binding domain-containing protein -
FIU12_RS25910 3553..3918 - 366 WP_025861963.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroB / vat 1..96085 96085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15227.68 Da        Isoelectric Point: 7.7805

>T127335 WP_001044773.1 NZ_CP040994:981-1397 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T127335 NZ_CP040994:981-1397 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAACCGTCCTGAAACGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8899.03 Da        Isoelectric Point: 4.5112

>AT127335 WP_001261277.1 NZ_CP040994:754-984 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT127335 NZ_CP040994:754-984 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
AGAGCTCGAGATCATCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421H508

Antitoxin

Source ID Structure
AlphaFold DB A0A060VSA5

References