Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 754..1397 | Replicon | plasmid unnamed2 |
Accession | NZ_CP040994 | ||
Organism | Klebsiella pneumoniae strain FDAARGOS_775 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A421H508 |
Locus tag | FIU12_RS25890 | Protein ID | WP_001044773.1 |
Coordinates | 981..1397 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A060VSA5 |
Locus tag | FIU12_RS25885 | Protein ID | WP_001261277.1 |
Coordinates | 754..984 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FIU12_RS25880 | 339..611 | + | 273 | WP_044246604.1 | DNA polymerase III subunit theta | - |
FIU12_RS25885 | 754..984 | + | 231 | WP_001261277.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
FIU12_RS25890 | 981..1397 | + | 417 | WP_001044773.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FIU12_RS25895 | 1456..1896 | - | 441 | Protein_4 | transposase family protein | - |
FIU12_RS27525 | 1884..2039 | - | 156 | WP_164993475.1 | hypothetical protein | - |
FIU12_RS25900 | 2253..2963 | - | 711 | Protein_6 | IS110 family transposase | - |
FIU12_RS25905 | 2970..3553 | - | 584 | Protein_7 | transposase zinc-binding domain-containing protein | - |
FIU12_RS25910 | 3553..3918 | - | 366 | WP_025861963.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | iroB / vat | 1..96085 | 96085 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15227.68 Da Isoelectric Point: 7.7805
>T127335 WP_001044773.1 NZ_CP040994:981-1397 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK
Download Length: 417 bp
>T127335 NZ_CP040994:981-1397 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAACCGTCCTGAAACGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAACCGTCCTGAAACGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8899.03 Da Isoelectric Point: 4.5112
>AT127335 WP_001261277.1 NZ_CP040994:754-984 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT127335 NZ_CP040994:754-984 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
AGAGCTCGAGATCATCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
AGAGCTCGAGATCATCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A421H508 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060VSA5 |