Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2537210..2537829 | Replicon | chromosome |
Accession | NZ_CP040993 | ||
Organism | Klebsiella pneumoniae strain FDAARGOS_775 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A377W829 |
Locus tag | FIU12_RS12620 | Protein ID | WP_025861658.1 |
Coordinates | 2537210..2537428 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | FIU12_RS12625 | Protein ID | WP_002892066.1 |
Coordinates | 2537455..2537829 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FIU12_RS12590 | 2533257..2533520 | + | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
FIU12_RS12595 | 2533520..2533660 | + | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
FIU12_RS12600 | 2533657..2534355 | - | 699 | WP_025861660.1 | GNAT family N-acetyltransferase | - |
FIU12_RS12605 | 2534456..2535907 | + | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
FIU12_RS12610 | 2535882..2536352 | - | 471 | WP_002892026.1 | YlaC family protein | - |
FIU12_RS27970 | 2536373..2536513 | + | 141 | WP_004147370.1 | hypothetical protein | - |
FIU12_RS12615 | 2536485..2537051 | - | 567 | WP_032443798.1 | maltose O-acetyltransferase | - |
FIU12_RS12620 | 2537210..2537428 | - | 219 | WP_025861658.1 | hemolysin expression modulator Hha | Toxin |
FIU12_RS12625 | 2537455..2537829 | - | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
FIU12_RS12630 | 2538315..2541461 | - | 3147 | WP_004147373.1 | multidrug efflux RND transporter permease subunit | - |
FIU12_RS12635 | 2541484..2542677 | - | 1194 | WP_004147376.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8644.00 Da Isoelectric Point: 8.9008
>T127325 WP_025861658.1 NZ_CP040993:c2537428-2537210 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELSVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELSVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T127325 NZ_CP040993:c2537428-2537210 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGTCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGTCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT127325 WP_002892066.1 NZ_CP040993:c2537829-2537455 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT127325 NZ_CP040993:c2537829-2537455 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A377W829 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |