Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1790128..1790644 Replicon chromosome
Accession NZ_CP040993
Organism Klebsiella pneumoniae strain FDAARGOS_775

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FIU12_RS09000 Protein ID WP_002886902.1
Coordinates 1790360..1790644 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FIU12_RS08995 Protein ID WP_002886901.1
Coordinates 1790128..1790370 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU12_RS08980 1786156..1786896 + 741 WP_002886899.1 KDGP aldolase family protein -
FIU12_RS08985 1786963..1788117 + 1155 WP_004146773.1 lactonase family protein -
FIU12_RS08990 1788140..1790050 + 1911 WP_004146774.1 BglG family transcription antiterminator -
FIU12_RS08995 1790128..1790370 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FIU12_RS09000 1790360..1790644 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU12_RS09005 1790648..1791112 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FIU12_RS09010 1791354..1793492 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FIU12_RS09015 1793849..1794592 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FIU12_RS27850 1794595..1794768 - 174 WP_004146781.1 hypothetical protein -
FIU12_RS09020 1794853..1795161 + 309 WP_016947038.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T127322 WP_002886902.1 NZ_CP040993:1790360-1790644 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T127322 NZ_CP040993:1790360-1790644 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT127322 WP_002886901.1 NZ_CP040993:1790128-1790370 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT127322 NZ_CP040993:1790128-1790370 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References