Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3313155..3314875 Replicon chromosome
Accession NZ_CP040933
Organism Edwardsiella ictaluri strain YCH

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag FGU63_RS15755 Protein ID WP_198077154.1
Coordinates 3314219..3314875 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag FGU63_RS15750 Protein ID WP_012849888.1
Coordinates 3313155..3314222 (-) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU63_RS15735 (FGU63_15655) 3308395..3308949 + 555 WP_049640356.1 hypothetical protein -
FGU63_RS15740 (FGU63_15660) 3309180..3309896 - 717 WP_198077153.1 SprT family zinc-dependent metalloprotease -
FGU63_RS15745 (FGU63_15665) 3309896..3312991 - 3096 WP_049640354.1 HsdR family type I site-specific deoxyribonuclease -
FGU63_RS15750 (FGU63_15670) 3313155..3314222 - 1068 WP_012849888.1 macro domain-containing protein Antitoxin
FGU63_RS15755 (FGU63_15675) 3314219..3314875 - 657 WP_198077154.1 DUF4433 domain-containing protein Toxin
FGU63_RS15760 (FGU63_15680) 3314888..3316282 - 1395 WP_232347307.1 restriction endonuclease subunit S -
FGU63_RS15765 (FGU63_15685) 3316276..3318714 - 2439 WP_198077155.1 type I restriction-modification system subunit M -
FGU63_RS15770 (FGU63_15690) 3318753..3318992 - 240 WP_015872655.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3305511..3320973 15462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25210.74 Da        Isoelectric Point: 6.9049

>T127312 WP_198077154.1 NZ_CP040933:c3314875-3314219 [Edwardsiella ictaluri]
MAYDYSANLNPEKALIWRIVHRDNIPWILDNGLHCGNSQVQAANWINIGNPELIGKRAGHPVPVGMGGTLHDYVPFYFTP
FSPMLMNIHSGRGGITQRPNEEIVILVSNLRNVAAQNIPFVFTDSHAYYNWVNYYTRLEDLNQIDWPILQARDFRRDPDD
PAKFERYQAEALIWKHCPITLLVGMICYNDGVRLQLEQWLSQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T127312 NZ_CP040933:c3314875-3314219 [Edwardsiella ictaluri]
ATGGCCTACGATTACAGCGCTAATCTCAACCCGGAAAAAGCCCTGATTTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACAACGGCCTGCACTGCGGCAACAGTCAAGTGCAGGCGGCAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGTATGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAATGAGGAAATCGTCATTCTGGT
CAGCAACCTGCGAAACGTGGCGGCGCAGAACATCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAACTGGGTCAACT
ACTACACCCGTCTGGAGGACCTGAATCAGATCGACTGGCCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGAAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40713.02 Da        Isoelectric Point: 6.9067

>AT127312 WP_012849888.1 NZ_CP040933:c3314222-3313155 [Edwardsiella ictaluri]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKAYAHACKQKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMAWIEDGLQDLRRFLIEKKVRSIAIPPLGAGNGGLNWPDVRARIESTLGDLQDTEILIYEPTEKYQNVAKSS
GVKKLTPARAMIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHINLWLNSEAKAWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGQCQPTLDSVKEG
LHQWPAGEPWASRKIKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT127312 NZ_CP040933:c3314222-3313155 [Edwardsiella ictaluri]
ATGATCACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCCACGCCTGCAAACAAAAGC
AGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGCGTGGATCGAAGACGGTTTGCAGGACCTGCGCCGCTTTTTGATCGAAAAGAA
AGTGCGGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCGGACGTCCGGGCGCGGATTGAAT
CTACGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCAGC
GGCGTAAAAAAGCTCACCCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGTATGGAGTGCAG
CCTGCTGGAAATTCAGAAGCTGGCATGGCTGCTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGCTAAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACCTGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGTATCCCGGACAGCCAGCCACTGGATGTGATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTCTG
GCTGAACAGCGAAGCCAAAGCGTGGTTACCAGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCCGGGGACAATGCCAGCCCACGCTGGACTCCGTGAAAGAAGGT
CTGCACCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGTAAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCAT
TAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References