Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/dnstrm_HI1420(antitoxin) |
| Location | 1983544..1984323 | Replicon | chromosome |
| Accession | NZ_CP040933 | ||
| Organism | Edwardsiella ictaluri strain YCH | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | - |
| Locus tag | FGU63_RS09470 | Protein ID | WP_198077053.1 |
| Coordinates | 1983544..1983801 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | C5BBM9 |
| Locus tag | FGU63_RS09475 | Protein ID | WP_015871334.1 |
| Coordinates | 1983811..1984323 (+) | Length | 171 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FGU63_RS09440 (FGU63_09380) | 1978740..1978984 | - | 245 | Protein_1814 | transposase | - |
| FGU63_RS09445 (FGU63_09385) | 1979090..1979908 | - | 819 | WP_198077051.1 | hypothetical protein | - |
| FGU63_RS09450 (FGU63_09390) | 1979973..1981313 | - | 1341 | WP_049640648.1 | Fic family protein | - |
| FGU63_RS09455 (FGU63_09395) | 1981442..1982212 | - | 771 | WP_198077052.1 | Rha family transcriptional regulator | - |
| FGU63_RS09460 (FGU63_09400) | 1982619..1982996 | + | 378 | WP_233420345.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FGU63_RS09465 (FGU63_09405) | 1983012..1983293 | + | 282 | WP_278068344.1 | helix-turn-helix transcriptional regulator | - |
| FGU63_RS09470 (FGU63_09410) | 1983544..1983801 | + | 258 | WP_198077053.1 | DUF4160 domain-containing protein | Toxin |
| FGU63_RS09475 (FGU63_09415) | 1983811..1984323 | + | 513 | WP_015871334.1 | DUF2442 domain-containing protein | Antitoxin |
| FGU63_RS09480 (FGU63_09420) | 1984395..1984694 | - | 300 | WP_049640646.1 | XRE family transcriptional regulator | - |
| FGU63_RS09485 (FGU63_09425) | 1984696..1985046 | - | 351 | WP_198077054.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FGU63_RS09490 (FGU63_09430) | 1985096..1985407 | - | 312 | WP_049640644.1 | DUF1364 family protein | - |
| FGU63_RS09495 (FGU63_09435) | 1985410..1986054 | - | 645 | WP_198077055.1 | DUF1367 family protein | - |
| FGU63_RS09500 (FGU63_09440) | 1986164..1986511 | - | 348 | WP_015871339.1 | hypothetical protein | - |
| FGU63_RS09505 (FGU63_09445) | 1986541..1987923 | - | 1383 | WP_049640642.1 | replicative DNA helicase | - |
| FGU63_RS09510 (FGU63_09450) | 1987920..1988870 | - | 951 | WP_198077056.1 | helix-turn-helix domain-containing protein | - |
| FGU63_RS09515 (FGU63_09455) | 1988874..1989062 | - | 189 | WP_198077057.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1947185..2005180 | 57995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9625.29 Da Isoelectric Point: 7.4665
>T127309 WP_198077053.1 NZ_CP040933:1983544-1983801 [Edwardsiella ictaluri]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL
Download Length: 258 bp
>T127309 NZ_CP040933:1983544-1983801 [Edwardsiella ictaluri]
ATGCCAGAGATTGATGCCCTGATGGGGCTAAGCTTTGTGATGTATTTCTTCGACAATCAAACTCACAGTTTGCCGCATGT
CCATGTGAAATACGGCGAATTTGAGCTGGTTATCGGGATCGACTCAGGAGAGGCCTTGGAGGGTTACCTTCCCCCTAAAA
AGAGGAAACTGGCCGAGTCACATATCAAGGCCAATAAAACCAGGCTACTGGCTATGTGGCAGATGGCGGTTAATGGGATG
CATCCTGGGAAACTGTAA
ATGCCAGAGATTGATGCCCTGATGGGGCTAAGCTTTGTGATGTATTTCTTCGACAATCAAACTCACAGTTTGCCGCATGT
CCATGTGAAATACGGCGAATTTGAGCTGGTTATCGGGATCGACTCAGGAGAGGCCTTGGAGGGTTACCTTCCCCCTAAAA
AGAGGAAACTGGCCGAGTCACATATCAAGGCCAATAAAACCAGGCTACTGGCTATGTGGCAGATGGCGGTTAATGGGATG
CATCCTGGGAAACTGTAA
Antitoxin
Download Length: 171 a.a. Molecular weight: 18155.52 Da Isoelectric Point: 7.3201
>AT127309 WP_015871334.1 NZ_CP040933:1983811-1984323 [Edwardsiella ictaluri]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLAALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRISKGAVVSASS
RALTPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG
MLKIIDVDVVGDHVIEVEFSDGFRGRADLAALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRISKGAVVSASS
RALTPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG
Download Length: 513 bp
>AT127309 NZ_CP040933:1983811-1984323 [Edwardsiella ictaluri]
ATGTTGAAAATTATTGATGTGGATGTGGTCGGCGACCATGTTATCGAGGTCGAATTTAGCGACGGCTTCCGTGGTAGGGC
TGATTTAGCCGCGCTGTTCAGCAAACCGCCCTTCTCTGCGATCGCCGACTTTAACCGCTTTTCCCTGACAGCCAGCGGCG
TGCTGAACTGGGGAGATGCCGAGCTTTCTGCCGATACGGTTAGGCGCATCAGCAAAGGCGCAGTGGTATCGGCATCCTCA
CGCGCACTCACGCCAGAAAATGTAGAAGCGATCCTCCGCCAGGCCACCTGGGAATCCATGAGCGAGGGGCGCCCGGATAT
TTTGCAGGCCGCGTTAAGGGGATACGCGGAGCAGCTGGGCCACGCGGACGTCATCAAGAGGGCCGGGATTGCCAGCCGCA
GCAGTGCATACAAAACGCTATCGCCATCAACGAACCCCAGCTTTAAATCGCTGGCAAAGATCAGCGGCGCGATTTTGGCT
ATCGTGCGTGAAAATAACGCGCAGCATGGTTAA
ATGTTGAAAATTATTGATGTGGATGTGGTCGGCGACCATGTTATCGAGGTCGAATTTAGCGACGGCTTCCGTGGTAGGGC
TGATTTAGCCGCGCTGTTCAGCAAACCGCCCTTCTCTGCGATCGCCGACTTTAACCGCTTTTCCCTGACAGCCAGCGGCG
TGCTGAACTGGGGAGATGCCGAGCTTTCTGCCGATACGGTTAGGCGCATCAGCAAAGGCGCAGTGGTATCGGCATCCTCA
CGCGCACTCACGCCAGAAAATGTAGAAGCGATCCTCCGCCAGGCCACCTGGGAATCCATGAGCGAGGGGCGCCCGGATAT
TTTGCAGGCCGCGTTAAGGGGATACGCGGAGCAGCTGGGCCACGCGGACGTCATCAAGAGGGCCGGGATTGCCAGCCGCA
GCAGTGCATACAAAACGCTATCGCCATCAACGAACCCCAGCTTTAAATCGCTGGCAAAGATCAGCGGCGCGATTTTGGCT
ATCGTGCGTGAAAATAACGCGCAGCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|