Detailed information of TA system TA127307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1971103..1971625
• Replicon: chromosome
• Accession: NZ_CP040933
• Organism: Edwardsiella ictaluri strain YCH

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: FGU63_RS09390
• Protein ID: WP_015871319.1
• Coordinates: 1971344..1971625 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: FGU63_RS09385
• Protein ID: WP_015871318.1
• Coordinates: 1971103..1971354 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGU63_RS09355 (FGU63_09300)	1966259..1966921	-	663	WP_015871312.1	hypothetical protein	-
FGU63_RS09360 (FGU63_09305)	1966921..1967481	-	561	WP_263115783.1	hypothetical protein	-
FGU63_RS09365 (FGU63_09310)	1967502..1967990	-	489	WP_289245685.1	hypothetical protein	-
FGU63_RS09370 (FGU63_09315)	1967987..1968382	-	396	WP_049640651.1	hypothetical protein	-
FGU63_RS09375 (FGU63_09320)	1968540..1969796	-	1257	WP_198077050.1	N4-gp56 family major capsid protein	-
FGU63_RS09380 (FGU63_09325)	1969814..1970815	-	1002	WP_015871317.1	hypothetical protein	-
FGU63_RS09385 (FGU63_09330)	1971103..1971354	+	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FGU63_RS09390 (FGU63_09335)	1971344..1971625	+	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FGU63_RS09395 (FGU63_09340)	1971697..1973811	-	2115	WP_015871320.1	hypothetical protein	-
FGU63_RS09400 (FGU63_09345)	1973808..1975469	-	1662	WP_050977403.1	terminase	-
FGU63_RS09405	1975462..1975884	-	423	WP_232347283.1	hypothetical protein	-
FGU63_RS09410	1976019..1976246	-	228	WP_232347284.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1947185..2005180	57995

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T127307 WP_015871319.1 NZ_CP040933:1971344-1971625 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T127307 NZ_CP040933:1971344-1971625 [Edwardsiella ictaluri]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT127307 WP_015871318.1 NZ_CP040933:1971103-1971354 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT127307 NZ_CP040933:1971103-1971354 [Edwardsiella ictaluri]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3