Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1116956..1117548 Replicon chromosome
Accession NZ_CP040933
Organism Edwardsiella ictaluri strain YCH

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag FGU63_RS05295 Protein ID WP_012847872.1
Coordinates 1116956..1117159 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag FGU63_RS05300 Protein ID WP_015870487.1
Coordinates 1117180..1117548 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU63_RS05255 (FGU63_05190) 1112176..1112637 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
FGU63_RS05260 1112666..1112833 - 168 WP_015870481.1 hypothetical protein -
FGU63_RS05265 (FGU63_05195) 1112936..1113274 + 339 WP_015870482.1 P-II family nitrogen regulator -
FGU63_RS05270 (FGU63_05200) 1113296..1114576 + 1281 WP_198077273.1 ammonium transporter AmtB -
FGU63_RS05275 (FGU63_05205) 1114610..1115476 - 867 WP_015870484.1 acyl-CoA thioesterase II -
FGU63_RS05280 (FGU63_05210) 1115522..1115851 - 330 WP_015870485.1 MGMT family protein -
FGU63_RS05290 (FGU63_05225) 1116829..1116936 + 108 Protein_1015 IS5/IS1182 family transposase -
FGU63_RS05295 (FGU63_05230) 1116956..1117159 - 204 WP_012847872.1 HHA domain-containing protein Toxin
FGU63_RS05300 (FGU63_05235) 1117180..1117548 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
FGU63_RS05305 (FGU63_05240) 1117908..1121060 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
FGU63_RS05310 (FGU63_05245) 1121104..1122288 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T127306 WP_012847872.1 NZ_CP040933:c1117159-1116956 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T127306 NZ_CP040933:c1117159-1116956 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT127306 WP_015870487.1 NZ_CP040933:c1117548-1117180 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT127306 NZ_CP040933:c1117548-1117180 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References