Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1081518..1082084 Replicon chromosome
Accession NZ_CP040931
Organism Bifidobacterium breve strain JR01

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag D3H49_RS04650 Protein ID WP_014483710.1
Coordinates 1081518..1081811 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag D3H49_RS04655 Protein ID WP_014483711.1
Coordinates 1081815..1082084 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3H49_RS04620 1076520..1076918 - 399 WP_016462921.1 hypothetical protein -
D3H49_RS04625 1076972..1077847 - 876 WP_021649674.1 ABC transporter ATP-binding protein -
D3H49_RS04630 1077900..1078682 - 783 WP_021649673.1 hypothetical protein -
D3H49_RS04635 1078679..1079305 - 627 WP_015438836.1 hypothetical protein -
D3H49_RS04640 1079437..1080264 - 828 WP_015438835.1 hypothetical protein -
D3H49_RS04645 1080298..1080849 - 552 WP_015438834.1 RNA polymerase sigma factor -
D3H49_RS04650 1081518..1081811 - 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
D3H49_RS04655 1081815..1082084 - 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D3H49_RS04660 1082269..1083438 - 1170 WP_051317546.1 ABC transporter permease -
D3H49_RS04665 1083435..1084123 - 689 Protein_905 ABC transporter ATP-binding protein -
D3H49_RS04670 1084120..1085010 - 891 WP_003831809.1 hypothetical protein -
D3H49_RS04675 1085007..1085522 - 516 WP_013140733.1 hypothetical protein -
D3H49_RS04680 1085648..1086343 + 696 WP_003829410.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1070576..1091625 21049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T127301 WP_014483710.1 NZ_CP040931:c1081811-1081518 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T127301 NZ_CP040931:c1081811-1081518 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT127301 WP_014483711.1 NZ_CP040931:c1082084-1081815 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT127301 NZ_CP040931:c1082084-1081815 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References