Detailed information of TA system TA127299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3959443..3960482
• Replicon: chromosome
• Accession: NZ_CP040930
• Organism: Pseudomonas sp. SWI7

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: FH041_RS18070
• Protein ID: WP_140174923.1
• Coordinates: 3959443..3960018 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A0S4I9D6
• Locus tag: FH041_RS18075
• Protein ID: WP_027913402.1
• Coordinates: 3960015..3960482 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH041_RS18050	3954523..3956364	+	1842	WP_049695298.1	amidohydrolase	-
FH041_RS18055	3956650..3957561	-	912	WP_027913398.1	LysR family transcriptional regulator	-
FH041_RS18060	3957690..3958487	-	798	WP_028686766.1	SDR family oxidoreductase	-
FH041_RS18065	3958487..3959263	-	777	WP_027913400.1	alpha/beta hydrolase	-
FH041_RS18070	3959443..3960018	-	576	WP_140174923.1	PIN domain-containing protein	Toxin
FH041_RS18075	3960015..3960482	-	468	WP_027913402.1	helix-turn-helix domain-containing protein	Antitoxin
FH041_RS18080	3960695..3962185	-	1491	WP_125921885.1	YifB family Mg chelatase-like AAA ATPase	-
FH041_RS18085	3962418..3964427	+	2010	WP_111475156.1	DUF4034 domain-containing protein	-
FH041_RS18090	3964463..3964720	-	258	WP_027913405.1	accessory factor UbiK family protein	-
FH041_RS18095	3965084..3965422	+	339	WP_002555808.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• SinI-like, DNA-binding domain (84-130)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21925.24 Da
• Isoelectric Point: 5.9326

>T127299 WP_140174923.1 NZ_CP040930:c3960018-3959443 [Pseudomonas sp. SWI7]
MRHSPFTVIYDACVLYPAPLRDLLMHLALTGAYRARWSEQIHDEWTRNVLRNRPDVSETQLYRTVGLMNRAIPDSLVNDY
EPLVQGLDLPDEDDRHVLAAAIKCGASVIVTYNLKDFPAEILKRFEIEALHPDVFLSDIRDLDQAAVLKAVQKQRAALNN
PVYSPRELLDILLKQRLPETVKHLSNYELLI

Nucleotide

• Length: 576 bp

>T127299 NZ_CP040930:c3960018-3959443 [Pseudomonas sp. SWI7]
ATGAGGCACTCACCTTTTACAGTTATCTACGACGCCTGCGTGCTTTATCCAGCACCATTGCGTGACCTATTGATGCATCT
GGCTCTGACTGGCGCGTATCGCGCGCGCTGGTCCGAGCAAATCCACGATGAATGGACACGAAACGTGTTAAGAAACCGTC
CCGACGTGTCAGAAACACAGCTTTATCGCACAGTCGGACTCATGAATCGGGCGATTCCTGACTCTCTGGTAAATGACTAC
GAGCCACTTGTGCAGGGGCTTGACCTTCCAGACGAAGACGATAGACACGTCTTGGCAGCAGCGATCAAATGTGGCGCCTC
GGTGATTGTCACGTACAACCTCAAAGATTTTCCGGCCGAGATTCTGAAACGTTTTGAGATCGAGGCGTTGCATCCCGATG
TATTCCTCTCCGACATCAGGGACCTTGATCAGGCAGCTGTGCTCAAGGCCGTCCAGAAGCAGCGCGCAGCCCTTAACAAT
CCGGTTTACTCACCCCGCGAGCTGCTGGACATCCTCCTCAAGCAGCGGCTCCCAGAGACCGTCAAGCACCTCTCGAACTA
CGAGCTGCTGATCTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17035.46 Da
• Isoelectric Point: 4.9896

>AT127299 WP_027913402.1 NZ_CP040930:c3960482-3960015 [Pseudomonas sp. SWI7]
MTTADLAQAILPDEKAITAAIESSRQIAAFVSTKLDTQRIELVDEAQQRQTVELPTFALRLLGDILNELALGNTVKVVPI
HAELTTQEGADMLNVSRPHLVKLLDEGLIPHTKTGSHRRVKFTDLMAYKADRDKASQAAMDELAAQAQELNMGYQ

Nucleotide

• Length: 468 bp

>AT127299 NZ_CP040930:c3960482-3960015 [Pseudomonas sp. SWI7]
ATGACTACCGCCGATCTCGCTCAAGCCATCCTTCCAGATGAAAAAGCGATCACCGCGGCTATTGAGTCAAGCCGCCAGAT
TGCCGCGTTCGTCTCAACCAAGTTGGATACTCAGCGCATTGAGTTGGTAGATGAAGCCCAGCAACGGCAGACTGTTGAAC
TGCCAACGTTCGCGCTCAGATTGCTTGGCGACATACTCAACGAGCTGGCCTTGGGCAACACCGTAAAGGTGGTGCCTATC
CATGCGGAACTGACCACCCAGGAGGGCGCCGATATGCTCAACGTCTCGCGTCCTCACTTGGTCAAGCTGCTGGATGAGGG
GCTAATCCCACACACCAAAACCGGCAGCCACCGCCGTGTAAAATTTACTGACCTAATGGCCTACAAGGCCGATCGTGATA
AAGCAAGCCAGGCCGCCATGGATGAACTGGCTGCACAAGCCCAAGAACTTAATATGGGCTATCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0S4I9D6