Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3125..3647 Replicon plasmid pYY76-1-2
Accession NZ_CP040929
Organism Escherichia coli strain YY76-1

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag FH040_RS23275 Protein ID WP_000220560.1
Coordinates 3366..3647 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag FH040_RS23270 Protein ID WP_000121743.1
Coordinates 3125..3376 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH040_RS23245 57..410 - 354 WP_000876434.1 hypothetical protein -
FH040_RS23250 547..993 - 447 WP_001074386.1 hypothetical protein -
FH040_RS23255 1033..1869 - 837 WP_001050931.1 replication initiation protein -
FH040_RS23270 3125..3376 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
FH040_RS23275 3366..3647 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FH040_RS23280 3793..4116 + 324 WP_001181903.1 hypothetical protein -
FH040_RS23285 4161..4406 + 246 WP_000356546.1 hypothetical protein -
FH040_RS23290 4396..4611 + 216 WP_001180116.1 hypothetical protein -
FH040_RS23295 4704..5033 + 330 WP_000866648.1 hypothetical protein -
FH040_RS23790 5320..5469 + 150 WP_000003880.1 hypothetical protein -
FH040_RS23300 5482..5754 + 273 WP_000160399.1 hypothetical protein -
FH040_RS23305 6081..6626 + 546 WP_038976855.1 hypothetical protein -
FH040_RS23310 6629..7786 + 1158 WP_000538023.1 hypothetical protein -
FH040_RS23315 8147..8638 + 492 WP_000872475.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / tet(A) / floR / tet(X4) / lnu(F) / aadA2 - 1..57104 57104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T127297 WP_000220560.1 NZ_CP040929:3366-3647 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T127297 NZ_CP040929:3366-3647 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT127297 WP_000121743.1 NZ_CP040929:3125-3376 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT127297 NZ_CP040929:3125-3376 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References